Cargando…

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of the motor neurons that innervate muscle, resulting in gradual paralysis and culminating in the inability to breathe or swallow. This neuronal degeneration occurs in a spatiotemporal manner from a point of onset i...

Descripción completa

Detalles Bibliográficos
Autores principales:	McAlary, Luke, Chew, Yee Lian, Lum, Jeremy Stephen, Geraghty, Nicholas John, Yerbury, Justin John, Cashman, Neil R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671971/ https://www.ncbi.nlm.nih.gov/pubmed/33328890 http://dx.doi.org/10.3389/fncel.2020.581907

Ejemplares similares

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis
por: McAlary, Luke, et al.
Publicado: (2019)

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis
por: McAlary, Luke, et al.
Publicado: (2020)

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis
por: McAlary, Luke, et al.
Publicado: (2013)

Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis?
por: Chisholm, Christen G., et al.
Publicado: (2022)

A copper chaperone–mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis
por: McAlary, L., et al.
Publicado: (2022)

Misfolding at the synapse: A role in amyotrophic lateral sclerosis pathogenesis?
por: Lum, Jeremy S., et al.
Publicado: (2022)

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
por: Crown, Anthony, et al.
Publicado: (2020)

Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis.
por: Yerbury, Justin J., et al.
Publicado: (2020)

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold
por: McAlary, Luke, et al.
Publicado: (2019)

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity
por: McAlary, Luke, et al.
Publicado: (2016)

Molecular Chaperones’ Potential against Defective Proteostasis of Amyotrophic Lateral Sclerosis
por: Kinger, Sumit, et al.
Publicado: (2023)

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells
por: Pokrishevsky, Edward, et al.
Publicado: (2018)

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases
por: McAlary, Luke, et al.
Publicado: (2019)

Assessment of protein inclusions in cultured cells using automated image analysis
por: McAlary, Luke, et al.
Publicado: (2022)

Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis
por: Benson, Bridget C., et al.
Publicado: (2021)

P2X7 receptor antagonism in amyotrophic lateral sclerosis
por: Sluyter, Ronald, et al.
Publicado: (2017)

Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?
por: Lee, Shynrye, et al.
Publicado: (2015)

Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms
por: Monahan, Zachary T., et al.
Publicado: (2018)

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis
por: Paez-Colasante, Ximena, et al.
Publicado: (2020)

Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?
por: Xue, Yuan Chao, et al.
Publicado: (2018)

GEMALS: A promising therapy for amyotrophic lateral sclerosis
por: Geffard, Michel, et al.
Publicado: (2018)

Dual Role of Lysophosphatidic Acid Receptor 2 (LPA(2)) in Amyotrophic Lateral Sclerosis
por: Puigdomenech-Poch, Maria, et al.
Publicado: (2021)

Emerging Evidence Highlighting the Importance of Redox Dysregulation in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)
por: Jagaraj, Cyril Jones, et al.
Publicado: (2021)

A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men
por: Martin, Sarah, et al.
Publicado: (2022)

Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis—a Systematic Review and Meta-Analysis of Preclinical Research
por: Elliott, Elizabeth, et al.
Publicado: (2020)

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS
por: Farrawell, Natalie E., et al.
Publicado: (2020)

Amyotrophic lateral sclerosis: promising therapeutic outcome–not far away?
por: Hajra, Adrija, et al.
Publicado: (2016)

Evolution of sequence traits of prion-like proteins linked to amyotrophic lateral sclerosis (ALS)
por: Luo, Jiayi, et al.
Publicado: (2022)

Breached Barriers: A Scoping Review of Blood-Central Nervous System Barrier Pathology in Amyotrophic Lateral Sclerosis
por: Mirian, Ario, et al.
Publicado: (2022)

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis
por: Hanspal, Maya A., et al.
Publicado: (2017)

Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
por: Kanouchi, Tadashi, et al.
Publicado: (2012)

Amyotrophic lateral sclerosis
por: Wijesekera, Lokesh C, et al.
Publicado: (2009)

Medulla oblongata volume as a promising predictor of survival in amyotrophic lateral sclerosis
por: Milella, Giammarco, et al.
Publicado: (2022)

Skeletal muscle in amyotrophic lateral sclerosis
por: Shefner, Jeremy M, et al.
Publicado: (2023)

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis
por: Buskila, Yossi, et al.
Publicado: (2019)

Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis
por: Chew, Sheena, et al.
Publicado: (2019)

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis
por: Paré, Bastien, et al.
Publicado: (2018)

Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis
por: Fabes, Jeremy, et al.
Publicado: (2017)

Amyotrophic lateral sclerosis and neuroregeneration
Publicado: (2012)

Mimickers of Amyotrophic Lateral Sclerosis
por: Dubey, Ayush, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ukk6igtf3vulqi7l6h4tv8b0et