Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microceph...

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Detalles Bibliográficos
Autores principales: Cicconi, Alessandro, Rai, Rekha, Xiong, Xuexue, Broton, Cayla, Al-Hiyasat, Amer, Hu, Chunyi, Dong, Siying, Sun, Wenqi, Garbarino, Jennifer, Bindra, Ranjit S., Schildkraut, Carl, Chen, Yong, Chang, Sandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672075/
https://www.ncbi.nlm.nih.gov/pubmed/33203878
http://dx.doi.org/10.1038/s41467-020-19674-0

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