Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with...

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Detalles Bibliográficos
Autores principales: Song, Lintao, Liu, Zhihua, Hu, Hui-Hui, Yang, Ying, Li, Terytty Yang, Lin, Zhi-Zhong, Ye, Jing, Chen, Jianing, Huang, Xi, Liu, Dong-Tai, Zhou, Jing, Shi, Yiran, Zhao, Hao, Xie, Changchuan, Chen, Lanfen, Song, Erwei, Lin, Shu-Yong, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672079/
https://www.ncbi.nlm.nih.gov/pubmed/33203880
http://dx.doi.org/10.1038/s41467-020-19694-w

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