The dynamic behavior of lipid droplets in the pre-metastatic niche

The pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immu...

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Detalles Bibliográficos
Autores principales: Shang, Chunliang, Qiao, Jie, Guo, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672095/
https://www.ncbi.nlm.nih.gov/pubmed/33203856
http://dx.doi.org/10.1038/s41419-020-03207-0
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author Shang, Chunliang
Qiao, Jie
Guo, Hongyan
author_facet Shang, Chunliang
Qiao, Jie
Guo, Hongyan
author_sort Shang, Chunliang
collection PubMed
description The pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed.
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spelling pubmed-76720952020-11-20 The dynamic behavior of lipid droplets in the pre-metastatic niche Shang, Chunliang Qiao, Jie Guo, Hongyan Cell Death Dis Review Article The pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed. Nature Publishing Group UK 2020-11-17 /pmc/articles/PMC7672095/ /pubmed/33203856 http://dx.doi.org/10.1038/s41419-020-03207-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Shang, Chunliang
Qiao, Jie
Guo, Hongyan
The dynamic behavior of lipid droplets in the pre-metastatic niche
title The dynamic behavior of lipid droplets in the pre-metastatic niche
title_full The dynamic behavior of lipid droplets in the pre-metastatic niche
title_fullStr The dynamic behavior of lipid droplets in the pre-metastatic niche
title_full_unstemmed The dynamic behavior of lipid droplets in the pre-metastatic niche
title_short The dynamic behavior of lipid droplets in the pre-metastatic niche
title_sort dynamic behavior of lipid droplets in the pre-metastatic niche
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672095/
https://www.ncbi.nlm.nih.gov/pubmed/33203856
http://dx.doi.org/10.1038/s41419-020-03207-0
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