Designed ferritin nanocages displaying trimeric TRAIL and tumor-targeting peptides confer superior anti-tumor efficacy

TRAIL is considered a promising target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing its functional receptors, DR4 or DR5. Although recombinant human TRAIL has shown high potency and specificity for killi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoo, Jae Do, Bae, Sang Mun, Seo, Junyoung, Jeon, In Seon, Vadevoo, Sri Murugan Poongkavithai, Kim, Sang-Yeob, Kim, In-San, Lee, Byungheon, Kim, Soyoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672110/
https://www.ncbi.nlm.nih.gov/pubmed/33203916
http://dx.doi.org/10.1038/s41598-020-77095-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672110/
https://www.ncbi.nlm.nih.gov/pubmed/33203916
http://dx.doi.org/10.1038/s41598-020-77095-x

Ejemplares similares