Cargando…

Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically

Background: Psychotic disorders are characterized by impairment in social cognitive processing, which is associated with poorer community functioning. However, the neural mechanisms of social impairment in psychosis remain unclear. Social impairment is a hallmark of other psychiatric illnesses as we...

Descripción completa

Detalles Bibliográficos
Autores principales: Brady, Roscoe O., Beermann, Adam, Nye, Madelaine, Eack, Shaun M., Mesholam-Gately, Raquelle, Keshavan, Matcheri S., Lewandowski, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672118/
https://www.ncbi.nlm.nih.gov/pubmed/33329111
http://dx.doi.org/10.3389/fpsyt.2020.573002
_version_ 1783611064063098880
author Brady, Roscoe O.
Beermann, Adam
Nye, Madelaine
Eack, Shaun M.
Mesholam-Gately, Raquelle
Keshavan, Matcheri S.
Lewandowski, Kathryn E.
author_facet Brady, Roscoe O.
Beermann, Adam
Nye, Madelaine
Eack, Shaun M.
Mesholam-Gately, Raquelle
Keshavan, Matcheri S.
Lewandowski, Kathryn E.
author_sort Brady, Roscoe O.
collection PubMed
description Background: Psychotic disorders are characterized by impairment in social cognitive processing, which is associated with poorer community functioning. However, the neural mechanisms of social impairment in psychosis remain unclear. Social impairment is a hallmark of other psychiatric illnesses as well, including autism spectrum disorders (ASD), and the nature and degree of social cognitive impairments across psychotic disorders and ASD are similar, suggesting that mechanisms that are known to underpin social impairments in ASD may also play a role in the impairments seen in psychosis. Specifically, in both humans and animal models of ASD, a cerebellar–parietal network has been identified that is directly related to social cognition and social functioning. In this study we examined social cognition and resting-state brain connectivity in people with psychosis and in neurotypical adults. We hypothesized that social cognition would be most strongly associated with cerebellar–parietal connectivity, even when using a whole-brain data driven approach. Methods: We examined associations between brain connectivity and social cognition in a trans-diagnostic sample of people with psychosis (n = 81) and neurotypical controls (n = 45). Social cognition was assessed using the social cognition domain score of the MATRICS Consensus Cognitive Battery. We used a multivariate pattern analysis to correlate social cognition with resting-state functional connectivity at the individual voxel level. Results: This approach identified a circuit between right cerebellar Crus I, II and left parietal cortex as the strongest correlate of social cognitive performance. This connectivity-cognition result was observed in both people with psychotic disorders and in neurotypical adults. Conclusions: Using a data-driven whole brain approach we identified a cerebellar–parietal circuit that was robustly associated with social cognitive ability, consistent with findings from people with ASD and animal models. These findings suggest that this circuit may be marker of social cognitive impairment trans-diagnostically and support cerebellar–parietal connectivity as a potential therapeutic target for enhancing social cognition.
format Online
Article
Text
id pubmed-7672118
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-76721182020-12-15 Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically Brady, Roscoe O. Beermann, Adam Nye, Madelaine Eack, Shaun M. Mesholam-Gately, Raquelle Keshavan, Matcheri S. Lewandowski, Kathryn E. Front Psychiatry Psychiatry Background: Psychotic disorders are characterized by impairment in social cognitive processing, which is associated with poorer community functioning. However, the neural mechanisms of social impairment in psychosis remain unclear. Social impairment is a hallmark of other psychiatric illnesses as well, including autism spectrum disorders (ASD), and the nature and degree of social cognitive impairments across psychotic disorders and ASD are similar, suggesting that mechanisms that are known to underpin social impairments in ASD may also play a role in the impairments seen in psychosis. Specifically, in both humans and animal models of ASD, a cerebellar–parietal network has been identified that is directly related to social cognition and social functioning. In this study we examined social cognition and resting-state brain connectivity in people with psychosis and in neurotypical adults. We hypothesized that social cognition would be most strongly associated with cerebellar–parietal connectivity, even when using a whole-brain data driven approach. Methods: We examined associations between brain connectivity and social cognition in a trans-diagnostic sample of people with psychosis (n = 81) and neurotypical controls (n = 45). Social cognition was assessed using the social cognition domain score of the MATRICS Consensus Cognitive Battery. We used a multivariate pattern analysis to correlate social cognition with resting-state functional connectivity at the individual voxel level. Results: This approach identified a circuit between right cerebellar Crus I, II and left parietal cortex as the strongest correlate of social cognitive performance. This connectivity-cognition result was observed in both people with psychotic disorders and in neurotypical adults. Conclusions: Using a data-driven whole brain approach we identified a cerebellar–parietal circuit that was robustly associated with social cognitive ability, consistent with findings from people with ASD and animal models. These findings suggest that this circuit may be marker of social cognitive impairment trans-diagnostically and support cerebellar–parietal connectivity as a potential therapeutic target for enhancing social cognition. Frontiers Media S.A. 2020-11-04 /pmc/articles/PMC7672118/ /pubmed/33329111 http://dx.doi.org/10.3389/fpsyt.2020.573002 Text en Copyright © 2020 Brady, Beermann, Nye, Eack, Mesholam-Gately, Keshavan and Lewandowski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Brady, Roscoe O.
Beermann, Adam
Nye, Madelaine
Eack, Shaun M.
Mesholam-Gately, Raquelle
Keshavan, Matcheri S.
Lewandowski, Kathryn E.
Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically
title Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically
title_full Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically
title_fullStr Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically
title_full_unstemmed Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically
title_short Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically
title_sort cerebellar-cortical connectivity is linked to social cognition trans-diagnostically
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672118/
https://www.ncbi.nlm.nih.gov/pubmed/33329111
http://dx.doi.org/10.3389/fpsyt.2020.573002
work_keys_str_mv AT bradyroscoeo cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically
AT beermannadam cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically
AT nyemadelaine cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically
AT eackshaunm cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically
AT mesholamgatelyraquelle cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically
AT keshavanmatcheris cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically
AT lewandowskikathryne cerebellarcorticalconnectivityislinkedtosocialcognitiontransdiagnostically