In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa

Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of cef...

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Autores principales: Carr, Donna, Zhang, Zufei, Si, Qian, Racine, Fred, Xiao, Jing Chen, Katwaru, Ravi, Wismer, Michael K, Johnson, Matthew G, Feng, Hwa-Ping, Young, Katherine, Rizk, Matthew L, Motyl, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672432/
https://www.ncbi.nlm.nih.gov/pubmed/33241064
http://dx.doi.org/10.1093/ofid/ofaa469
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author Carr, Donna
Zhang, Zufei
Si, Qian
Racine, Fred
Xiao, Jing Chen
Katwaru, Ravi
Wismer, Michael K
Johnson, Matthew G
Feng, Hwa-Ping
Young, Katherine
Rizk, Matthew L
Motyl, Mary
author_facet Carr, Donna
Zhang, Zufei
Si, Qian
Racine, Fred
Xiao, Jing Chen
Katwaru, Ravi
Wismer, Michael K
Johnson, Matthew G
Feng, Hwa-Ping
Young, Katherine
Rizk, Matthew L
Motyl, Mary
author_sort Carr, Donna
collection PubMed
description Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of ceftolozane/tazobactam at and above approved breakpoints against multidrug-resistant Pseudomonas aeruginosa, regardless of Pseudomonas-derived cephalosporinase allele.
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spelling pubmed-76724322020-11-24 In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa Carr, Donna Zhang, Zufei Si, Qian Racine, Fred Xiao, Jing Chen Katwaru, Ravi Wismer, Michael K Johnson, Matthew G Feng, Hwa-Ping Young, Katherine Rizk, Matthew L Motyl, Mary Open Forum Infect Dis Brief Reports Our hollow-fiber infection model simulated the projected steady-state pharmacokinetics of ceftolozane and tazobactam in lung epithelial lining fluid of patients with pneumonia receiving 3 g of ceftolozane/tazobactam every 8 hours. Results confirmed the previously established in vitro activity of ceftolozane/tazobactam at and above approved breakpoints against multidrug-resistant Pseudomonas aeruginosa, regardless of Pseudomonas-derived cephalosporinase allele. Oxford University Press 2020-10-08 /pmc/articles/PMC7672432/ /pubmed/33241064 http://dx.doi.org/10.1093/ofid/ofaa469 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Carr, Donna
Zhang, Zufei
Si, Qian
Racine, Fred
Xiao, Jing Chen
Katwaru, Ravi
Wismer, Michael K
Johnson, Matthew G
Feng, Hwa-Ping
Young, Katherine
Rizk, Matthew L
Motyl, Mary
In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa
title In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa
title_full In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa
title_fullStr In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa
title_full_unstemmed In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa
title_short In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa
title_sort in vitro hollow-fiber studies assessing antibacterial activity of ceftolozane/tazobactam against multidrug-resistant pseudomonas aeruginosa
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672432/
https://www.ncbi.nlm.nih.gov/pubmed/33241064
http://dx.doi.org/10.1093/ofid/ofaa469
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