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Mechanisms of replication and repair in mitochondrial DNA deletion formation

Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases in length and the loss of these associated genes contributes to crippled oxidative phosphorylation and overall decline in mit...

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Detalles Bibliográficos
Autores principales: Fontana, Gabriele A, Gahlon, Hailey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672454/
https://www.ncbi.nlm.nih.gov/pubmed/33021629
http://dx.doi.org/10.1093/nar/gkaa804