Statistical mechanics of chromosomes: in vivo and in silico approaches reveal high-level organization and structure arise exclusively through mechanical feedback between loop extruders and chromatin substrate properties

The revolution in understanding higher order chromosome dynamics and organization derives from treating the chromosome as a chain polymer and adapting appropriate polymer-based physical principles. Using basic principles, such as entropic fluctuations and timescales of relaxation of Rouse polymer ch...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Yunyan, Lawrimore, Josh, Cook, Diana, Van Gorder, Elizabeth Erin, De Larimat, Solenn Claire, Adalsteinsson, David, Forest, M Gregory, Bloom, Kerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672462/
https://www.ncbi.nlm.nih.gov/pubmed/33080019
http://dx.doi.org/10.1093/nar/gkaa871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672462/
https://www.ncbi.nlm.nih.gov/pubmed/33080019
http://dx.doi.org/10.1093/nar/gkaa871

Ejemplares similares