Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization

IRF3 and IRF7 are critical transcription factors in the innate immune response. Their activation is controlled by phosphorylation events, leading to the formation of homodimers that are transcriptionally active. Phosphorylation occurs when IRF3 is recruited to adaptor proteins via a positively charg...

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Detalles Bibliográficos
Autores principales: Dalskov, Louise, Narita, Ryo, Andersen, Line L, Jensen, Nanna, Assil, Sonia, Kristensen, Kennith H, Mikkelsen, Jacob G, Fujita, Takashi, Mogensen, Trine H, Paludan, Søren R, Hartmann, Rune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672473/
https://www.ncbi.nlm.nih.gov/pubmed/33205822
http://dx.doi.org/10.1093/nar/gkaa873

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