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Patterned Piezoelectric Scaffolds for Osteogenic Differentiation

The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroact...

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Detalles Bibliográficos
Autores principales: Marques-Almeida, Teresa, Cardoso, Vanessa F., Gama, Miguel, Lanceros-Mendez, Senentxu, Ribeiro, Clarisse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672637/
https://www.ncbi.nlm.nih.gov/pubmed/33171761
http://dx.doi.org/10.3390/ijms21218352
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author Marques-Almeida, Teresa
Cardoso, Vanessa F.
Gama, Miguel
Lanceros-Mendez, Senentxu
Ribeiro, Clarisse
author_facet Marques-Almeida, Teresa
Cardoso, Vanessa F.
Gama, Miguel
Lanceros-Mendez, Senentxu
Ribeiro, Clarisse
author_sort Marques-Almeida, Teresa
collection PubMed
description The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration.
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spelling pubmed-76726372020-11-19 Patterned Piezoelectric Scaffolds for Osteogenic Differentiation Marques-Almeida, Teresa Cardoso, Vanessa F. Gama, Miguel Lanceros-Mendez, Senentxu Ribeiro, Clarisse Int J Mol Sci Article The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration. MDPI 2020-11-07 /pmc/articles/PMC7672637/ /pubmed/33171761 http://dx.doi.org/10.3390/ijms21218352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marques-Almeida, Teresa
Cardoso, Vanessa F.
Gama, Miguel
Lanceros-Mendez, Senentxu
Ribeiro, Clarisse
Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
title Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
title_full Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
title_fullStr Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
title_full_unstemmed Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
title_short Patterned Piezoelectric Scaffolds for Osteogenic Differentiation
title_sort patterned piezoelectric scaffolds for osteogenic differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672637/
https://www.ncbi.nlm.nih.gov/pubmed/33171761
http://dx.doi.org/10.3390/ijms21218352
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