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Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota
During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intest...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672645/ https://www.ncbi.nlm.nih.gov/pubmed/33114008 http://dx.doi.org/10.3390/ijms21217863 |
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author | Alauzet, Corentine Cunat, Lisiane Wack, Maxime Lanfumey, Laurence Legrand-Frossi, Christine Lozniewski, Alain Agrinier, Nelly Cailliez-Grimal, Catherine Frippiat, Jean-Pol |
author_facet | Alauzet, Corentine Cunat, Lisiane Wack, Maxime Lanfumey, Laurence Legrand-Frossi, Christine Lozniewski, Alain Agrinier, Nelly Cailliez-Grimal, Catherine Frippiat, Jean-Pol |
author_sort | Alauzet, Corentine |
collection | PubMed |
description | During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intestinal microbiota in a murine model used to mimic chronic psychosocial stressors encountered during a long-term space mission. We demonstrate that 3 weeks of exposure to this model (called CUMS for Chronic Unpredictable Mild Stress) induce significant change in intracaecal β-diversity characterized by an important increase of the Firmicutes/Bacteroidetes ratio. These alterations are associated with a decrease of Porphyromonadaceae, particularly of the genus Barnesiella, a major member of gut microbiota in mice and humans where it is described as having protective properties. These results raise the question of the impact of stress-induced decrease of beneficial taxa, support recent data deduced from in-flight experimentations and other ground-based models, and emphasize the critical need for further studies exploring the impact of spaceflight on intestinal microbiota in order to propose strategies to countermeasure spaceflight-associated dysbiosis and its consequences on health. |
format | Online Article Text |
id | pubmed-7672645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76726452020-11-19 Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota Alauzet, Corentine Cunat, Lisiane Wack, Maxime Lanfumey, Laurence Legrand-Frossi, Christine Lozniewski, Alain Agrinier, Nelly Cailliez-Grimal, Catherine Frippiat, Jean-Pol Int J Mol Sci Article During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intestinal microbiota in a murine model used to mimic chronic psychosocial stressors encountered during a long-term space mission. We demonstrate that 3 weeks of exposure to this model (called CUMS for Chronic Unpredictable Mild Stress) induce significant change in intracaecal β-diversity characterized by an important increase of the Firmicutes/Bacteroidetes ratio. These alterations are associated with a decrease of Porphyromonadaceae, particularly of the genus Barnesiella, a major member of gut microbiota in mice and humans where it is described as having protective properties. These results raise the question of the impact of stress-induced decrease of beneficial taxa, support recent data deduced from in-flight experimentations and other ground-based models, and emphasize the critical need for further studies exploring the impact of spaceflight on intestinal microbiota in order to propose strategies to countermeasure spaceflight-associated dysbiosis and its consequences on health. MDPI 2020-10-23 /pmc/articles/PMC7672645/ /pubmed/33114008 http://dx.doi.org/10.3390/ijms21217863 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alauzet, Corentine Cunat, Lisiane Wack, Maxime Lanfumey, Laurence Legrand-Frossi, Christine Lozniewski, Alain Agrinier, Nelly Cailliez-Grimal, Catherine Frippiat, Jean-Pol Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota |
title | Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota |
title_full | Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota |
title_fullStr | Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota |
title_full_unstemmed | Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota |
title_short | Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota |
title_sort | impact of a model used to simulate chronic socio-environmental stressors encountered during spaceflight on murine intestinal microbiota |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672645/ https://www.ncbi.nlm.nih.gov/pubmed/33114008 http://dx.doi.org/10.3390/ijms21217863 |
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