Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis

AIM: We aimed to show the immunohistochemical expression of programmed death ligand 1 (PD-L1) in laryngeal squamous cell carcinomas (SCCs). MATERIALS AND METHODS: The study includes 52 laryngeal SCC cases that underwent surgical resection. Immunohistochemical staining of PD-L1 (Clone 22C3) was appli...

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Autores principales: Batur, Sebnem, Kain, Zeynep Ecem, Gozen, Emine Deniz, Kepil, Nuray, Aydin, Ovgu, Comunoglu, Nil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Focus Section: Novel Therapies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672728/
https://www.ncbi.nlm.nih.gov/pubmed/33241207
http://dx.doi.org/10.1177/2632010X20964846
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author Batur, Sebnem
Kain, Zeynep Ecem
Gozen, Emine Deniz
Kepil, Nuray
Aydin, Ovgu
Comunoglu, Nil
author_facet Batur, Sebnem
Kain, Zeynep Ecem
Gozen, Emine Deniz
Kepil, Nuray
Aydin, Ovgu
Comunoglu, Nil
author_sort Batur, Sebnem
collection PubMed
description AIM: We aimed to show the immunohistochemical expression of programmed death ligand 1 (PD-L1) in laryngeal squamous cell carcinomas (SCCs). MATERIALS AND METHODS: The study includes 52 laryngeal SCC cases that underwent surgical resection. Immunohistochemical staining of PD-L1 (Clone 22C3) was applied to the sections obtained from paraffin blocks. Combined Positive Score (CPS) was evaluated as described in manuals. Tumor Proportion Score (TPS) was assessed by the percentage of positive tumor cells which were designated as positive if ⩾1% of the tumor cells showed membranous staining. RESULTS: There were 35 cases (67.3%) having CPS < 1 and 17 cases (32.7%) having CPS ⩾ 1. There was no relationship between CPS, TPS, and the clinicopathological data. CONCLUSION: Further studies with a large number of advanced-stage cases are needed.
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spelling pubmed-76727282020-11-24 Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis Batur, Sebnem Kain, Zeynep Ecem Gozen, Emine Deniz Kepil, Nuray Aydin, Ovgu Comunoglu, Nil Clin Pathol Focus Section: Novel Therapies AIM: We aimed to show the immunohistochemical expression of programmed death ligand 1 (PD-L1) in laryngeal squamous cell carcinomas (SCCs). MATERIALS AND METHODS: The study includes 52 laryngeal SCC cases that underwent surgical resection. Immunohistochemical staining of PD-L1 (Clone 22C3) was applied to the sections obtained from paraffin blocks. Combined Positive Score (CPS) was evaluated as described in manuals. Tumor Proportion Score (TPS) was assessed by the percentage of positive tumor cells which were designated as positive if ⩾1% of the tumor cells showed membranous staining. RESULTS: There were 35 cases (67.3%) having CPS < 1 and 17 cases (32.7%) having CPS ⩾ 1. There was no relationship between CPS, TPS, and the clinicopathological data. CONCLUSION: Further studies with a large number of advanced-stage cases are needed. SAGE Publications 2020-11-12 /pmc/articles/PMC7672728/ /pubmed/33241207 http://dx.doi.org/10.1177/2632010X20964846 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Focus Section: Novel Therapies
Batur, Sebnem
Kain, Zeynep Ecem
Gozen, Emine Deniz
Kepil, Nuray
Aydin, Ovgu
Comunoglu, Nil
Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
title Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
title_full Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
title_fullStr Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
title_full_unstemmed Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
title_short Programmed Death Ligand 1 Expression in Laryngeal Squamous Cell Carcinomas and Prognosis
title_sort programmed death ligand 1 expression in laryngeal squamous cell carcinomas and prognosis
topic Focus Section: Novel Therapies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672728/
https://www.ncbi.nlm.nih.gov/pubmed/33241207
http://dx.doi.org/10.1177/2632010X20964846
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