Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids

BACKGROUND: Human immunodeficiency virus type-1 (HIV-1) and opiates cause long-term inflammatory insult to the central nervous system (CNS) and worsen disease progression and HIV-1-related neuropathology. The combination of these proinflammatory factors reflects a devastating problem as opioids have...

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Detalles Bibliográficos
Autores principales: Hermes, Douglas J., Jacobs, Ian R., Key, Megan C., League, Alexis F., Yadav-Samudrala, Barkha J., Xu, Changqing, McLane, Virginia D., Nass, Sara R., Jiang, Wei, Meeker, Rick B., Ignatowska-Jankowska, Bogna M., Lichtman, Aron H., Li, Zibo, Wu, Zhanhong, Yuan, Hong, Knapp, Pamela E., Hauser, Kurt F., Fitting, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672881/
https://www.ncbi.nlm.nih.gov/pubmed/33208151
http://dx.doi.org/10.1186/s12974-020-01971-6

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