Cargando…

The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization

BACKGROUND: Over the past decade, the exponential growth of the literature devoted to personalized medicine has been paralleled by an ever louder chorus of epistemic and ethical criticisms. Their differences notwithstanding, both advocates and critics share an outdated philosophical understanding of...

Descripción completa

Detalles Bibliográficos
Autores principales: Abettan, Camille, Welie, Jos V. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672902/
https://www.ncbi.nlm.nih.gov/pubmed/33203434
http://dx.doi.org/10.1186/s13010-020-00095-2
_version_ 1783611228271149056
author Abettan, Camille
Welie, Jos V. M.
author_facet Abettan, Camille
Welie, Jos V. M.
author_sort Abettan, Camille
collection PubMed
description BACKGROUND: Over the past decade, the exponential growth of the literature devoted to personalized medicine has been paralleled by an ever louder chorus of epistemic and ethical criticisms. Their differences notwithstanding, both advocates and critics share an outdated philosophical understanding of the concept of personhood and hence tend to assume too simplistic an understanding of personalization in health care. METHODS: In this article, we question this philosophical understanding of personhood and personalization, as these concepts shape the field of personalized medicine. We establish a dialogue with phenomenology and hermeneutics (especially with E. Husserl, M. Merleau-Ponty and P. Ricoeur) in order to achieve a more sophisticated understanding of the meaning of these concepts We particularly focus on the relationship between personal subjectivity and objective data. RESULTS: We first explore the gap between the ideal of personalized healthcare and the reality of today’s personalized medicine. We show that the nearly exclusive focus of personalized medicine on the objective part of personhood leads to a flawed ethical debate that needs to be reframed. Second, we seek to contribute to this reframing by drawing on the phenomenological-hermeneutical movement in philosophy. Third, we show that these admittedly theoretical analyses open up new conceptual possibilities to tackle the very practical ethical challenges that personalized medicine faces. CONCLUSION: Finally, we propose a reversal: if personalization is a continuous process by which the person reappropriates all manner of objective data, giving them meaning and thereby shaping his or her own way of being human, then personalized medicine, rather than being personalized itself, can facilitate personalization of those it serves through the data it provides.
format Online
Article
Text
id pubmed-7672902
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-76729022020-11-19 The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization Abettan, Camille Welie, Jos V. M. Philos Ethics Humanit Med Research BACKGROUND: Over the past decade, the exponential growth of the literature devoted to personalized medicine has been paralleled by an ever louder chorus of epistemic and ethical criticisms. Their differences notwithstanding, both advocates and critics share an outdated philosophical understanding of the concept of personhood and hence tend to assume too simplistic an understanding of personalization in health care. METHODS: In this article, we question this philosophical understanding of personhood and personalization, as these concepts shape the field of personalized medicine. We establish a dialogue with phenomenology and hermeneutics (especially with E. Husserl, M. Merleau-Ponty and P. Ricoeur) in order to achieve a more sophisticated understanding of the meaning of these concepts We particularly focus on the relationship between personal subjectivity and objective data. RESULTS: We first explore the gap between the ideal of personalized healthcare and the reality of today’s personalized medicine. We show that the nearly exclusive focus of personalized medicine on the objective part of personhood leads to a flawed ethical debate that needs to be reframed. Second, we seek to contribute to this reframing by drawing on the phenomenological-hermeneutical movement in philosophy. Third, we show that these admittedly theoretical analyses open up new conceptual possibilities to tackle the very practical ethical challenges that personalized medicine faces. CONCLUSION: Finally, we propose a reversal: if personalization is a continuous process by which the person reappropriates all manner of objective data, giving them meaning and thereby shaping his or her own way of being human, then personalized medicine, rather than being personalized itself, can facilitate personalization of those it serves through the data it provides. BioMed Central 2020-11-18 /pmc/articles/PMC7672902/ /pubmed/33203434 http://dx.doi.org/10.1186/s13010-020-00095-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Abettan, Camille
Welie, Jos V. M.
The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
title The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
title_full The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
title_fullStr The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
title_full_unstemmed The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
title_short The impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
title_sort impact of twenty-first century personalized medicine versus twenty-first century medicine’s impact on personalization
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672902/
https://www.ncbi.nlm.nih.gov/pubmed/33203434
http://dx.doi.org/10.1186/s13010-020-00095-2
work_keys_str_mv AT abettancamille theimpactoftwentyfirstcenturypersonalizedmedicineversustwentyfirstcenturymedicinesimpactonpersonalization
AT weliejosvm theimpactoftwentyfirstcenturypersonalizedmedicineversustwentyfirstcenturymedicinesimpactonpersonalization
AT abettancamille impactoftwentyfirstcenturypersonalizedmedicineversustwentyfirstcenturymedicinesimpactonpersonalization
AT weliejosvm impactoftwentyfirstcenturypersonalizedmedicineversustwentyfirstcenturymedicinesimpactonpersonalization