PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming

Pyruvate dehydrogenase kinase 4 (PDK4) is an important mitochondrial matrix enzyme in cellular energy regulation. Previous studies suggested that PDK4 is increased in the calcified vessels of patients with atherosclerosis and is closely associated with mitochondrial function, but the precise regulat...

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Detalles Bibliográficos
Autores principales: Ma, Wen-Qi, Sun, Xue-Jiao, Zhu, Yi, Liu, Nai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673024/
https://www.ncbi.nlm.nih.gov/pubmed/33203874
http://dx.doi.org/10.1038/s41419-020-03162-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673024/
https://www.ncbi.nlm.nih.gov/pubmed/33203874
http://dx.doi.org/10.1038/s41419-020-03162-w

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