Immune suppression in the early stage of COVID-19 disease

The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteom...

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Autores principales: Tian, Wenmin, Zhang, Nan, Jin, Ronghua, Feng, Yingmei, Wang, Siyuan, Gao, Shuaixin, Gao, Ruqin, Wu, Guizhen, Tian, Di, Tan, Wenjie, Chen, Yang, Gao, George Fu, Wong, Catherine C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673112/
https://www.ncbi.nlm.nih.gov/pubmed/33203833
http://dx.doi.org/10.1038/s41467-020-19706-9
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author Tian, Wenmin
Zhang, Nan
Jin, Ronghua
Feng, Yingmei
Wang, Siyuan
Gao, Shuaixin
Gao, Ruqin
Wu, Guizhen
Tian, Di
Tan, Wenjie
Chen, Yang
Gao, George Fu
Wong, Catherine C. L.
author_facet Tian, Wenmin
Zhang, Nan
Jin, Ronghua
Feng, Yingmei
Wang, Siyuan
Gao, Shuaixin
Gao, Ruqin
Wu, Guizhen
Tian, Di
Tan, Wenjie
Chen, Yang
Gao, George Fu
Wong, Catherine C. L.
author_sort Tian, Wenmin
collection PubMed
description The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies.
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spelling pubmed-76731122020-11-24 Immune suppression in the early stage of COVID-19 disease Tian, Wenmin Zhang, Nan Jin, Ronghua Feng, Yingmei Wang, Siyuan Gao, Shuaixin Gao, Ruqin Wu, Guizhen Tian, Di Tan, Wenjie Chen, Yang Gao, George Fu Wong, Catherine C. L. Nat Commun Article The outbreak of COVID-19 has become a worldwide pandemic. The pathogenesis of this infectious disease and how it differs from other drivers of pneumonia is unclear. Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients. We propose a two-stage mechanism of pathogenesis for this unusual viral infection. Our data advance our understanding of the clinical features of COVID-19 infections and provide a resource for future mechanistic and therapeutics studies. Nature Publishing Group UK 2020-11-17 /pmc/articles/PMC7673112/ /pubmed/33203833 http://dx.doi.org/10.1038/s41467-020-19706-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tian, Wenmin
Zhang, Nan
Jin, Ronghua
Feng, Yingmei
Wang, Siyuan
Gao, Shuaixin
Gao, Ruqin
Wu, Guizhen
Tian, Di
Tan, Wenjie
Chen, Yang
Gao, George Fu
Wong, Catherine C. L.
Immune suppression in the early stage of COVID-19 disease
title Immune suppression in the early stage of COVID-19 disease
title_full Immune suppression in the early stage of COVID-19 disease
title_fullStr Immune suppression in the early stage of COVID-19 disease
title_full_unstemmed Immune suppression in the early stage of COVID-19 disease
title_short Immune suppression in the early stage of COVID-19 disease
title_sort immune suppression in the early stage of covid-19 disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673112/
https://www.ncbi.nlm.nih.gov/pubmed/33203833
http://dx.doi.org/10.1038/s41467-020-19706-9
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