Cargando…

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors. Antibody...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Deli, Tran, Jenny Tuyet, Olson, Alex, Vollbrecht, Thomas, Tenuta, Mary, Guryleva, Mariia V., Fuller, Roberta P., Schiffner, Torben, Abadejos, Justin R., Couvrette, Lauren, Blane, Tanya R., Saye, Karen, Li, Wenjuan, Landais, Elise, Gonzalez-Martin, Alicia, Schief, William, Murrell, Ben, Burton, Dennis R., Nemazee, David, Voss, James E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673113/ https://www.ncbi.nlm.nih.gov/pubmed/33203876 http://dx.doi.org/10.1038/s41467-020-19650-8

Ejemplares similares

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
por: Huang, Deli, et al.
Publicado: (2020)

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
por: Umotoy, Jeffrey, et al.
Publicado: (2019)

Induction of Cross-Reactive and Protective Antibody Responses After DNA Vaccination With MHCII-Targeted Stem Domain From Influenza Hemagglutinin
por: Grødeland, Gunnveig, et al.
Publicado: (2020)

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design
por: Irimia, Adriana, et al.
Publicado: (2017)

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
por: Huang, Deli, et al.
Publicado: (2020)

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
por: Sok, Devin, et al.
Publicado: (2017)

In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice
por: Nahmad, A. D., et al.
Publicado: (2022)

Disease in the Pld4(thss/thss) Model of Murine Lupus Requires TLR9
por: Gavin, Amanda L., et al.
Publicado: (2023)

HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies
por: Sheward, Daniel J., et al.
Publicado: (2022)

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
por: Gavin, Amanda L., et al.
Publicado: (2021)

Designer antigens for elicitation of broadly neutralizing antibodies against HIV
por: Kok, Tuckweng, et al.
Publicado: (2014)

Efficient isolation of rare B cells using next-generation antigen barcoding
por: Hurtado, Jonathan, et al.
Publicado: (2023)

Prediabetes Induced by a Single Autoimmune B Cell Clone
por: Phillips, Nathaniel, et al.
Publicado: (2020)

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
por: Willis, Jordan R., et al.
Publicado: (2022)

Reprogramming the antigen specificity of B cells using genome-editing technologies
por: Voss, James E, et al.
Publicado: (2019)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
por: Walls, Alexandra C., et al.
Publicado: (2021)

Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
por: Landais, Elise, et al.
Publicado: (2018)

Stabilized coronavirus spike stem elicits a broadly protective antibody
por: Hsieh, Ching-Lin, et al.
Publicado: (2021)

Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies
por: Joyce, Collin, et al.
Publicado: (2023)

Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology
por: Hills, Rory A., et al.
Publicado: (2023)

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
por: Walls, Alexandra C., et al.
Publicado: (2021)

Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
por: Ahmed, Yousuf, et al.
Publicado: (2017)

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2021)

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
por: Steichen, Jon M., et al.
Publicado: (2016)

Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology
por: Nemazee, D, et al.
Publicado: (2012)

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
por: Kanekiyo, Masaru, et al.
Publicado: (2019)

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19
por: Rappazzo, C. Garrett, et al.
Publicado: (2020)

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
por: Jardine, Joseph G., et al.
Publicado: (2016)

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
por: McCoy, Laura E., et al.
Publicado: (2012)

Baculovirus Displaying Hemagglutinin Elicits Broad Cross-Protection against Influenza in Mice
por: Sim, Sang-Hee, et al.
Publicado: (2016)

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
por: Conti, Simone, et al.
Publicado: (2022)

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice
por: Wegmann, Frank, et al.
Publicado: (2015)

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity
por: Joyce, M. Gordon, et al.
Publicado: (2021)

SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity
por: Joyce, M. Gordon, et al.
Publicado: (2021)

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
por: Jardine, Joseph G., et al.
Publicado: (2016)

Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2
por: Luo, Mengxiao, et al.
Publicado: (2023)

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
por: Rappazzo, C. Garrett, et al.
Publicado: (2021)

SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ocsparjnihssv0gbcj4874oq1v