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Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS

OBJECTIVE: To explore the hypothesis that serum neurofilament light chain (sNfL) indicative of neuroaxonal damage may improve precise disease profiling with regard to cognition and neuropsychiatric symptoms, we analyzed potential associations of sNfL levels with cognitive test scores, fatigue, depre...

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Autores principales: Aktas, Orhan, Renner, Alina, Huss, André, Filser, Melanie, Baetge, Sharon, Stute, Nathalie, Gasis, Marcia, Lepka, Klaudia, Goebels, Norbert, Senel, Makbule, Graf, Jonas, Enzinger, Christian, Pinter, Daniela, Antoch, Gerald, Turowski, Bernd, Hartung, Hans-Peter, Albrecht, Philipp, Otto, Markus, Tumani, Hayrettin, Penner, Iris-Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673283/
https://www.ncbi.nlm.nih.gov/pubmed/32972970
http://dx.doi.org/10.1212/NXI.0000000000000885
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author Aktas, Orhan
Renner, Alina
Huss, André
Filser, Melanie
Baetge, Sharon
Stute, Nathalie
Gasis, Marcia
Lepka, Klaudia
Goebels, Norbert
Senel, Makbule
Graf, Jonas
Enzinger, Christian
Pinter, Daniela
Antoch, Gerald
Turowski, Bernd
Hartung, Hans-Peter
Albrecht, Philipp
Otto, Markus
Tumani, Hayrettin
Penner, Iris-Katharina
author_facet Aktas, Orhan
Renner, Alina
Huss, André
Filser, Melanie
Baetge, Sharon
Stute, Nathalie
Gasis, Marcia
Lepka, Klaudia
Goebels, Norbert
Senel, Makbule
Graf, Jonas
Enzinger, Christian
Pinter, Daniela
Antoch, Gerald
Turowski, Bernd
Hartung, Hans-Peter
Albrecht, Philipp
Otto, Markus
Tumani, Hayrettin
Penner, Iris-Katharina
author_sort Aktas, Orhan
collection PubMed
description OBJECTIVE: To explore the hypothesis that serum neurofilament light chain (sNfL) indicative of neuroaxonal damage may improve precise disease profiling with regard to cognition and neuropsychiatric symptoms, we analyzed potential associations of sNfL levels with cognitive test scores, fatigue, depression, and anxiety. METHODS: Patients with relapsing-remitting and secondary progressive MS (SPMS) underwent an elaborated assessment including MRI, various cognitive tests, and patient-reported outcomes. We determined sNfL levels by single molecule array (Simoa) assay. Relationships between sNfL, cognition, neuropsychiatric symptoms, and demographical data were analyzed using correlations, group comparisons, and regressions. RESULTS: In 45 clinically stable patients with MS (Expanded Disability Status Scale = 2.73 ± 1.12, disease duration = 10.03 ± 7.49 years), 40.0% were cognitively impaired. Mean sNfL levels were 16.02 ± 10.39 pg/mL, with higher levels in the SPMS subgroup (p = 0.038). sNfL levels did reliably link neither with the investigated cognitive and affective parameters nor with fatigue levels. The only relationship found in a small subgroup of patients with SPMS (n = 7) with visuospatial learning (r = −0.950, p = 0.001) and memory (r = −0.813; p = 0.026) disappeared when further controlling for age, educational level, and sex. CONCLUSIONS: In patients with stable MS at less advanced disease stages, sNfL did not convincingly relate to cognitive performance, fatigue, depression, or anxiety and thus may not serve as a surrogate biomarker for neuropsychological status in such populations.
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spelling pubmed-76732832020-11-19 Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS Aktas, Orhan Renner, Alina Huss, André Filser, Melanie Baetge, Sharon Stute, Nathalie Gasis, Marcia Lepka, Klaudia Goebels, Norbert Senel, Makbule Graf, Jonas Enzinger, Christian Pinter, Daniela Antoch, Gerald Turowski, Bernd Hartung, Hans-Peter Albrecht, Philipp Otto, Markus Tumani, Hayrettin Penner, Iris-Katharina Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: To explore the hypothesis that serum neurofilament light chain (sNfL) indicative of neuroaxonal damage may improve precise disease profiling with regard to cognition and neuropsychiatric symptoms, we analyzed potential associations of sNfL levels with cognitive test scores, fatigue, depression, and anxiety. METHODS: Patients with relapsing-remitting and secondary progressive MS (SPMS) underwent an elaborated assessment including MRI, various cognitive tests, and patient-reported outcomes. We determined sNfL levels by single molecule array (Simoa) assay. Relationships between sNfL, cognition, neuropsychiatric symptoms, and demographical data were analyzed using correlations, group comparisons, and regressions. RESULTS: In 45 clinically stable patients with MS (Expanded Disability Status Scale = 2.73 ± 1.12, disease duration = 10.03 ± 7.49 years), 40.0% were cognitively impaired. Mean sNfL levels were 16.02 ± 10.39 pg/mL, with higher levels in the SPMS subgroup (p = 0.038). sNfL levels did reliably link neither with the investigated cognitive and affective parameters nor with fatigue levels. The only relationship found in a small subgroup of patients with SPMS (n = 7) with visuospatial learning (r = −0.950, p = 0.001) and memory (r = −0.813; p = 0.026) disappeared when further controlling for age, educational level, and sex. CONCLUSIONS: In patients with stable MS at less advanced disease stages, sNfL did not convincingly relate to cognitive performance, fatigue, depression, or anxiety and thus may not serve as a surrogate biomarker for neuropsychological status in such populations. Lippincott Williams & Wilkins 2020-09-24 /pmc/articles/PMC7673283/ /pubmed/32972970 http://dx.doi.org/10.1212/NXI.0000000000000885 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Aktas, Orhan
Renner, Alina
Huss, André
Filser, Melanie
Baetge, Sharon
Stute, Nathalie
Gasis, Marcia
Lepka, Klaudia
Goebels, Norbert
Senel, Makbule
Graf, Jonas
Enzinger, Christian
Pinter, Daniela
Antoch, Gerald
Turowski, Bernd
Hartung, Hans-Peter
Albrecht, Philipp
Otto, Markus
Tumani, Hayrettin
Penner, Iris-Katharina
Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS
title Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS
title_full Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS
title_fullStr Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS
title_full_unstemmed Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS
title_short Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS
title_sort serum neurofilament light chain: no clear relation to cognition and neuropsychiatric symptoms in stable ms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673283/
https://www.ncbi.nlm.nih.gov/pubmed/32972970
http://dx.doi.org/10.1212/NXI.0000000000000885
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