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Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus)
ABH antigens are histo-antigens, but were first described on the surface of human erythrocytes. They are found in those cells only in great apes and humans, while in more primitive animals they are found in tissues and body fluids. ABH antigens are mainly distributed in tissues that are in contact w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673508/ https://www.ncbi.nlm.nih.gov/pubmed/33206689 http://dx.doi.org/10.1371/journal.pone.0241487 |
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author | Aguiar, Délia Cristina Figueira Pereira, Washington Luiz Assunção de Matos, Gyselly de Cássia Bastos Marruaz da Silva, Klena Sarges de Loiola, Rosane do Socorro Pompeu Corvelo, Tereza Cristina Oliveira |
author_facet | Aguiar, Délia Cristina Figueira Pereira, Washington Luiz Assunção de Matos, Gyselly de Cássia Bastos Marruaz da Silva, Klena Sarges de Loiola, Rosane do Socorro Pompeu Corvelo, Tereza Cristina Oliveira |
author_sort | Aguiar, Délia Cristina Figueira |
collection | PubMed |
description | ABH antigens are histo-antigens, but were first described on the surface of human erythrocytes. They are found in those cells only in great apes and humans, while in more primitive animals they are found in tissues and body fluids. ABH antigens are mainly distributed in tissues that are in contact with the external environment and may serve as ligands for pathogens in tissues or block their connection. Description of the distribution of these molecules in non-human primate tissues is restricted to a few tissues and species. This paper describes the expression of human A, B and H type antigens in different organs from four species of New World Primates, obtained from the Centro Nacional de Primatas, as well as comparing that expression with what has been described for humans. In this study, although the tissue description of the antigens is similar to the genetic model for humans, some differences in expression between some organs from those species and those of humans were found. The differences occurred mainly in endodermal organs that have secretory functions and are probably under the control of the human-type FUT-2 enzyme. In the mesodermal-origin organs there was a reduction or absence of A and B antigen marking, particularly in the H precursor substance, indicating that those organs are under the control of the human-type FUT-1 enzyme. These findings have demonstrated that there is similar ABH antigen reactivity in tissue distribution between the species, although there are some species-specific cases. |
format | Online Article Text |
id | pubmed-7673508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76735082020-11-19 Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) Aguiar, Délia Cristina Figueira Pereira, Washington Luiz Assunção de Matos, Gyselly de Cássia Bastos Marruaz da Silva, Klena Sarges de Loiola, Rosane do Socorro Pompeu Corvelo, Tereza Cristina Oliveira PLoS One Research Article ABH antigens are histo-antigens, but were first described on the surface of human erythrocytes. They are found in those cells only in great apes and humans, while in more primitive animals they are found in tissues and body fluids. ABH antigens are mainly distributed in tissues that are in contact with the external environment and may serve as ligands for pathogens in tissues or block their connection. Description of the distribution of these molecules in non-human primate tissues is restricted to a few tissues and species. This paper describes the expression of human A, B and H type antigens in different organs from four species of New World Primates, obtained from the Centro Nacional de Primatas, as well as comparing that expression with what has been described for humans. In this study, although the tissue description of the antigens is similar to the genetic model for humans, some differences in expression between some organs from those species and those of humans were found. The differences occurred mainly in endodermal organs that have secretory functions and are probably under the control of the human-type FUT-2 enzyme. In the mesodermal-origin organs there was a reduction or absence of A and B antigen marking, particularly in the H precursor substance, indicating that those organs are under the control of the human-type FUT-1 enzyme. These findings have demonstrated that there is similar ABH antigen reactivity in tissue distribution between the species, although there are some species-specific cases. Public Library of Science 2020-11-18 /pmc/articles/PMC7673508/ /pubmed/33206689 http://dx.doi.org/10.1371/journal.pone.0241487 Text en © 2020 Aguiar et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Aguiar, Délia Cristina Figueira Pereira, Washington Luiz Assunção de Matos, Gyselly de Cássia Bastos Marruaz da Silva, Klena Sarges de Loiola, Rosane do Socorro Pompeu Corvelo, Tereza Cristina Oliveira Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) |
title | Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) |
title_full | Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) |
title_fullStr | Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) |
title_full_unstemmed | Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) |
title_short | Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus) |
title_sort | tissue expression of antigens of abh blood groups in species of new world monkeys (aotus infulatus, callithrix jacchus, sapajus apella and saimiri sciureus) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673508/ https://www.ncbi.nlm.nih.gov/pubmed/33206689 http://dx.doi.org/10.1371/journal.pone.0241487 |
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