Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age
BACKGROUND: Rational medication use for treatment is mandatory, particularly in children as they are vulnerable to possible hazards of drugs. Understanding the medication use pattern is of importance to identify the problems of drug therapy and to improve the appropriate use of medication among this...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673523/ https://www.ncbi.nlm.nih.gov/pubmed/33206684 http://dx.doi.org/10.1371/journal.pone.0242410 |
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author | At Thobari, Jarir Satria, Cahya Dewi Ridora, Yohanes Watts, Emma Handley, Amanda Standish, Jane Bachtiar, Novilia S. Buttery, Jim P. Soenarto, Yati Bines, Julie E. |
author_facet | At Thobari, Jarir Satria, Cahya Dewi Ridora, Yohanes Watts, Emma Handley, Amanda Standish, Jane Bachtiar, Novilia S. Buttery, Jim P. Soenarto, Yati Bines, Julie E. |
author_sort | At Thobari, Jarir |
collection | PubMed |
description | BACKGROUND: Rational medication use for treatment is mandatory, particularly in children as they are vulnerable to possible hazards of drugs. Understanding the medication use pattern is of importance to identify the problems of drug therapy and to improve the appropriate use of medication among this population. METHODS: A post-hoc study of the RV3-BB Phase IIb trial to children aged 0–18 months which was conducted in Indonesia during January 2013 to July 2016. Any concomitant medication use and health events among 1621 trial participants during the 18 months of follow-up were documented. Information on medication use included the frequency, formulation, indication, duration of usage, number of regimens, medication types, and therapeutic classes. RESULTS: The majority of participants (N = 1333/1621; 82.2%) used at least one non-antibiotic medication for treatment during the 18-month observation period. A total of 7586 medication uses were recorded, mostly in oral formulation (90.5%). Of all illnesses recorded, 24.7% were treated with a single drug regimen of non-antibiotic medication. The most common therapeutic classes used were analgesics/antipyretics (30.1%), antihistamines for systemic use (17.4%), cough and cold preparations (13.5%), vitamins (8.6%), and antidiarrheals (6.6%). The main medication types used were paracetamol (29.9%), chlorpheniramine (16.8%), guaifenesin (8.9%), zinc (4.6%), and ambroxol (4.1%). Respiratory system disorder was the most common reason for medication use (51.9%), followed by gastrointestinal disorders (19.2%), pyrexia (16.9%), and skin disorders (7.0%). CONCLUSION: A large number of children were exposed to at least one medication during their early life, including those where evidence of efficacy and safety in a pediatric population is lacking. This supports the need for further research on pediatric drug therapy to improve the appropriate use of medication in this population. |
format | Online Article Text |
id | pubmed-7673523 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76735232020-11-19 Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age At Thobari, Jarir Satria, Cahya Dewi Ridora, Yohanes Watts, Emma Handley, Amanda Standish, Jane Bachtiar, Novilia S. Buttery, Jim P. Soenarto, Yati Bines, Julie E. PLoS One Research Article BACKGROUND: Rational medication use for treatment is mandatory, particularly in children as they are vulnerable to possible hazards of drugs. Understanding the medication use pattern is of importance to identify the problems of drug therapy and to improve the appropriate use of medication among this population. METHODS: A post-hoc study of the RV3-BB Phase IIb trial to children aged 0–18 months which was conducted in Indonesia during January 2013 to July 2016. Any concomitant medication use and health events among 1621 trial participants during the 18 months of follow-up were documented. Information on medication use included the frequency, formulation, indication, duration of usage, number of regimens, medication types, and therapeutic classes. RESULTS: The majority of participants (N = 1333/1621; 82.2%) used at least one non-antibiotic medication for treatment during the 18-month observation period. A total of 7586 medication uses were recorded, mostly in oral formulation (90.5%). Of all illnesses recorded, 24.7% were treated with a single drug regimen of non-antibiotic medication. The most common therapeutic classes used were analgesics/antipyretics (30.1%), antihistamines for systemic use (17.4%), cough and cold preparations (13.5%), vitamins (8.6%), and antidiarrheals (6.6%). The main medication types used were paracetamol (29.9%), chlorpheniramine (16.8%), guaifenesin (8.9%), zinc (4.6%), and ambroxol (4.1%). Respiratory system disorder was the most common reason for medication use (51.9%), followed by gastrointestinal disorders (19.2%), pyrexia (16.9%), and skin disorders (7.0%). CONCLUSION: A large number of children were exposed to at least one medication during their early life, including those where evidence of efficacy and safety in a pediatric population is lacking. This supports the need for further research on pediatric drug therapy to improve the appropriate use of medication in this population. Public Library of Science 2020-11-18 /pmc/articles/PMC7673523/ /pubmed/33206684 http://dx.doi.org/10.1371/journal.pone.0242410 Text en © 2020 At Thobari et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article At Thobari, Jarir Satria, Cahya Dewi Ridora, Yohanes Watts, Emma Handley, Amanda Standish, Jane Bachtiar, Novilia S. Buttery, Jim P. Soenarto, Yati Bines, Julie E. Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age |
title | Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age |
title_full | Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age |
title_fullStr | Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age |
title_full_unstemmed | Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age |
title_short | Non-antibiotic medication use in an Indonesian community cohort 0–18 months of age |
title_sort | non-antibiotic medication use in an indonesian community cohort 0–18 months of age |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673523/ https://www.ncbi.nlm.nih.gov/pubmed/33206684 http://dx.doi.org/10.1371/journal.pone.0242410 |
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