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B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns

Ehrlich solid carcinoma (ESC) is one of the tumor models used in cancer research. Although it is widely used, it has no ultrasonographic descriptions. In this study, serial B-mode and Doppler ultrasonographic examinations were performed for 23 days for ESCs inoculated into 18 Swiss albino mice. The...

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Autores principales: Castelló, Carla Martí, Miguel, Marina Pacheco, Silveira-Lacerda, Elisângela de Paula, Bakuzis, Andris Figueiroa, Borges, Naida Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673667/
https://www.ncbi.nlm.nih.gov/pubmed/33251133
http://dx.doi.org/10.3389/fonc.2020.560413
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author Castelló, Carla Martí
Miguel, Marina Pacheco
Silveira-Lacerda, Elisângela de Paula
Bakuzis, Andris Figueiroa
Borges, Naida Cristina
author_facet Castelló, Carla Martí
Miguel, Marina Pacheco
Silveira-Lacerda, Elisângela de Paula
Bakuzis, Andris Figueiroa
Borges, Naida Cristina
author_sort Castelló, Carla Martí
collection PubMed
description Ehrlich solid carcinoma (ESC) is one of the tumor models used in cancer research. Although it is widely used, it has no ultrasonographic descriptions. In this study, serial B-mode and Doppler ultrasonographic examinations were performed for 23 days for ESCs inoculated into 18 Swiss albino mice. The growth patterns were analyzed, and on the basis of their growth curve, the tumors were classified into two groups: fast growth (FG) and slow growth (SG). Ultrasonographic characteristics of the tumor’s capsule, margins, echogenicity, echotexture, vascular index (VI), distribution of vascular flow, and Doppler indices such as the resistive index, pulsatility index, and peak systolic velocity (SV) were analyzed and compared between the two groups. A high VI and earlier blood flow were noted in the FG group (p<0.05). Additionally, SV was higher in the FG group than in the SG group (13.28 ± 0.38 cm/s vs. 8.43 ± 0.26 cm/s). In contrast, a change in echogenicity and flow distribution patterns were observed, especially in FG tumors. Therefore, ESC presented with few ultrasonographic differences between FG and SG tumors, especially vascularization during the initial stages of tumor growth.
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spelling pubmed-76736672020-11-26 B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns Castelló, Carla Martí Miguel, Marina Pacheco Silveira-Lacerda, Elisângela de Paula Bakuzis, Andris Figueiroa Borges, Naida Cristina Front Oncol Oncology Ehrlich solid carcinoma (ESC) is one of the tumor models used in cancer research. Although it is widely used, it has no ultrasonographic descriptions. In this study, serial B-mode and Doppler ultrasonographic examinations were performed for 23 days for ESCs inoculated into 18 Swiss albino mice. The growth patterns were analyzed, and on the basis of their growth curve, the tumors were classified into two groups: fast growth (FG) and slow growth (SG). Ultrasonographic characteristics of the tumor’s capsule, margins, echogenicity, echotexture, vascular index (VI), distribution of vascular flow, and Doppler indices such as the resistive index, pulsatility index, and peak systolic velocity (SV) were analyzed and compared between the two groups. A high VI and earlier blood flow were noted in the FG group (p<0.05). Additionally, SV was higher in the FG group than in the SG group (13.28 ± 0.38 cm/s vs. 8.43 ± 0.26 cm/s). In contrast, a change in echogenicity and flow distribution patterns were observed, especially in FG tumors. Therefore, ESC presented with few ultrasonographic differences between FG and SG tumors, especially vascularization during the initial stages of tumor growth. Frontiers Media S.A. 2020-11-04 /pmc/articles/PMC7673667/ /pubmed/33251133 http://dx.doi.org/10.3389/fonc.2020.560413 Text en Copyright © 2020 Castelló, Miguel, Silveira-Lacerda, Bakuzis and Borges http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Castelló, Carla Martí
Miguel, Marina Pacheco
Silveira-Lacerda, Elisângela de Paula
Bakuzis, Andris Figueiroa
Borges, Naida Cristina
B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns
title B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns
title_full B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns
title_fullStr B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns
title_full_unstemmed B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns
title_short B-Mode and Doppler Ultrasonography in a Murine Model of Ehrlich Solid Carcinoma With Different Growth Patterns
title_sort b-mode and doppler ultrasonography in a murine model of ehrlich solid carcinoma with different growth patterns
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673667/
https://www.ncbi.nlm.nih.gov/pubmed/33251133
http://dx.doi.org/10.3389/fonc.2020.560413
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