Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

Disordered proteins are challenging therapeutic targets, and no drug is currently in clinical use that modifies the properties of their monomeric states. Here, we identify a small molecule (10074-G5) capable of binding and sequestering the intrinsically disordered amyloid-β (Aβ) peptide in its monom...

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Detalles Bibliográficos
Autores principales: Heller, Gabriella T., Aprile, Francesco A., Michaels, Thomas C. T., Limbocker, Ryan, Perni, Michele, Ruggeri, Francesco Simone, Mannini, Benedetta, Löhr, Thomas, Bonomi, Massimiliano, Camilloni, Carlo, De Simone, Alfonso, Felli, Isabella C., Pierattelli, Roberta, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673680/
https://www.ncbi.nlm.nih.gov/pubmed/33148639
http://dx.doi.org/10.1126/sciadv.abb5924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673680/
https://www.ncbi.nlm.nih.gov/pubmed/33148639
http://dx.doi.org/10.1126/sciadv.abb5924

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