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Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder

Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infectio...

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Autores principales: Jang, Tae-Min, Lee, Joong Hoon, Zhou, Honglei, Joo, Jaesun, Lim, Bong Hee, Cheng, Huanyu, Kim, Soo Hyun, Kang, Il-Suk, Lee, Kyu-Sung, Park, Eunkyoung, Hwang, Suk-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673729/
https://www.ncbi.nlm.nih.gov/pubmed/33177091
http://dx.doi.org/10.1126/sciadv.abc9675
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author Jang, Tae-Min
Lee, Joong Hoon
Zhou, Honglei
Joo, Jaesun
Lim, Bong Hee
Cheng, Huanyu
Kim, Soo Hyun
Kang, Il-Suk
Lee, Kyu-Sung
Park, Eunkyoung
Hwang, Suk-Won
author_facet Jang, Tae-Min
Lee, Joong Hoon
Zhou, Honglei
Joo, Jaesun
Lim, Bong Hee
Cheng, Huanyu
Kim, Soo Hyun
Kang, Il-Suk
Lee, Kyu-Sung
Park, Eunkyoung
Hwang, Suk-Won
author_sort Jang, Tae-Min
collection PubMed
description Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infections or life-threatening kidney damage. Here, we present an integrated expandable electronic and optoelectronic complex that behaves as a single body with the elastic, time-dynamic urinary bladder with substantial volume changes up to ~300%. The system configuration of the electronics validated by the theoretical model allows conformal, seamless integration onto the urinary bladder without a glue or suture, enabling precise monitoring with various electrical components for real-time status and efficient optogenetic manipulation for urination at the desired time. In vivo experiments using diabetic DUA models demonstrate the possibility for practical uses of high-fidelity electronics in clinical trials associated with the bladder and other elastic organs.
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spelling pubmed-76737292020-11-24 Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder Jang, Tae-Min Lee, Joong Hoon Zhou, Honglei Joo, Jaesun Lim, Bong Hee Cheng, Huanyu Kim, Soo Hyun Kang, Il-Suk Lee, Kyu-Sung Park, Eunkyoung Hwang, Suk-Won Sci Adv Research Articles Underactive bladder or detrusor underactivity (DUA), that is, not being able to micturate, has received less attention with little research and remains unknown or limited on pathological causes and treatments as opposed to overactive bladder, although the syndrome may pose a risk of urinary infections or life-threatening kidney damage. Here, we present an integrated expandable electronic and optoelectronic complex that behaves as a single body with the elastic, time-dynamic urinary bladder with substantial volume changes up to ~300%. The system configuration of the electronics validated by the theoretical model allows conformal, seamless integration onto the urinary bladder without a glue or suture, enabling precise monitoring with various electrical components for real-time status and efficient optogenetic manipulation for urination at the desired time. In vivo experiments using diabetic DUA models demonstrate the possibility for practical uses of high-fidelity electronics in clinical trials associated with the bladder and other elastic organs. American Association for the Advancement of Science 2020-11-11 /pmc/articles/PMC7673729/ /pubmed/33177091 http://dx.doi.org/10.1126/sciadv.abc9675 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Jang, Tae-Min
Lee, Joong Hoon
Zhou, Honglei
Joo, Jaesun
Lim, Bong Hee
Cheng, Huanyu
Kim, Soo Hyun
Kang, Il-Suk
Lee, Kyu-Sung
Park, Eunkyoung
Hwang, Suk-Won
Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
title Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
title_full Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
title_fullStr Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
title_full_unstemmed Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
title_short Expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
title_sort expandable and implantable bioelectronic complex for analyzing and regulating real-time activity of the urinary bladder
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673729/
https://www.ncbi.nlm.nih.gov/pubmed/33177091
http://dx.doi.org/10.1126/sciadv.abc9675
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