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Determinants of seeding and spreading of α-synuclein pathology in the brain

In Parkinson’s disease (PD), fibrillar forms of α-synuclein are hypothesized to propagate through synaptically coupled networks, causing Lewy pathology (LP) and neurodegeneration. To more rigorously characterize the determinants of spreading, preformed α-synuclein fibrils were injected into the mous...

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Detalles Bibliográficos
Autores principales:	Henrich, Martin T., Geibl, Fanni F., Lakshminarasimhan, Harini, Stegmann, Anna, Giasson, Benoit I., Mao, Xiaobo, Dawson, Valina L., Dawson, Ted M., Oertel, Wolfgang H., Surmeier, D. James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673735/ https://www.ncbi.nlm.nih.gov/pubmed/33177086 http://dx.doi.org/10.1126/sciadv.abc2487

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