Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome

Immune checkpoint inhibitors (ICIs) show promise, but most patients do not respond. We identify and validate biomarkers from extracellular vesicles (EVs), allowing non-invasive monitoring of tumor- intrinsic and host immune status, as well as a prediction of ICI response. We undertook transcriptomic...

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Detalles Bibliográficos
Autores principales: Shi, Alvin, Kasumova, Gyulnara G., Michaud, William A., Cintolo-Gonzalez, Jessica, Díaz-Martínez, Marta, Ohmura, Jacqueline, Mehta, Arnav, Chien, Isabel, Frederick, Dennie T., Cohen, Sonia, Plana, Deborah, Johnson, Douglas, Flaherty, Keith T., Sullivan, Ryan J., Kellis, Manolis, Boland, Genevieve M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673759/
https://www.ncbi.nlm.nih.gov/pubmed/33188016
http://dx.doi.org/10.1126/sciadv.abb3461

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