Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus

Lupus nephritis (LN) is an autoimmune disease with substantial morbidity/mortality and limited efficacy of available therapies. Memory T (Tm) lymphocytes infiltrate LN kidneys, contributing to organ damage. Analysis of LN, diabetic nephropathy, and healthy donor kidney biopsies revealed high infiltr...

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Detalles Bibliográficos
Autores principales: Khodoun, Marat, Chimote, Ameet A., Ilyas, Farhan Z., Duncan, Heather J., Moncrieffe, Halima, Kant, K. Shashi, Conforti, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673800/
https://www.ncbi.nlm.nih.gov/pubmed/33208373
http://dx.doi.org/10.1126/sciadv.abd1471

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