Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss

The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but its therapeutic potential in pathological bone loss remains unexplored. Here, we report that LPL knockout mice show increased bone mass and cortical thickness with more mononuclear tartrate-resistant acid...

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Detalles Bibliográficos
Autores principales: Li, Xiaoqun, Wang, Lipeng, Huang, Biaotong, Gu, Yanqiu, Luo, Ying, Zhi, Xin, Hu, Yan, Zhang, Hao, Gu, Zhengrong, Cui, Jin, Cao, Liehu, Guo, Jiawei, Wang, Yajun, Zhou, Qirong, Jiang, Hao, Fang, Chao, Weng, Weizong, Chen, Xiaofei, Chen, Xiao, Su, Jiacan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673802/
https://www.ncbi.nlm.nih.gov/pubmed/33208358
http://dx.doi.org/10.1126/sciadv.abb7135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673802/
https://www.ncbi.nlm.nih.gov/pubmed/33208358
http://dx.doi.org/10.1126/sciadv.abb7135

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