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Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly cleaves GSDMD to trigger pyroptosis. However, the molecular requirements for caspase-8–dependent GSDMD cleavage and the physiolog...

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Detalles Bibliográficos
Autores principales:	Demarco, Benjamin, Grayczyk, James P., Bjanes, Elisabet, Le Roy, Didier, Tonnus, Wulf, Assenmacher, Charles-Antoine, Radaelli, Enrico, Fettrelet, Timothée, Mack, Vanessa, Linkermann, Andreas, Roger, Thierry, Brodsky, Igor E., Chen, Kaiwen W., Broz, Petr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673803/ https://www.ncbi.nlm.nih.gov/pubmed/33208362 http://dx.doi.org/10.1126/sciadv.abc3465

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