A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells

Advances in treating β cell loss include islet replacement therapies or increasing cell proliferation rate in type 1 and type 2 diabetes, respectively. We propose developing multiple proliferation-inducing prodrugs that target high concentration of zinc ions in β cells. Unfortunately, typical two-di...

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Detalles Bibliográficos
Autores principales: Yang, Kisuk, Lee, Miseon, Jones, Peter Anthony, Liu, Sophie S., Zhou, Angela, Xu, Jun, Sreekanth, Vedagopuram, Wu, Jamie L. Y., Vo, Lillian, Lee, Eunjee A., Pop, Ramona, Lee, Yuhan, Wagner, Bridget K., Melton, Douglas A., Choudhary, Amit, Karp, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673808/
https://www.ncbi.nlm.nih.gov/pubmed/33208361
http://dx.doi.org/10.1126/sciadv.abc3207

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