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Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models

Cystic fibrosis (CF) results from mutations in the chloride-conducting CF transmembrane conductance regulator (CFTR) gene. Airway dehydration and impaired mucociliary clearance in CF is proposed to result in tonic epithelial sodium channel (ENaC) activity, which drives amiloride-sensitive electrogen...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Anindit, MacDonald, Kelvin D., Kim, Jeonghwan, Henderson, Michael I., Eygeris, Yulia, Sahay, Gaurav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673816/ https://www.ncbi.nlm.nih.gov/pubmed/33208364 http://dx.doi.org/10.1126/sciadv.abc5911

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