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Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population

PURPOSE: Multiple sclerosis (MS) is an autoimmune disease, and genetic factors play an important role in its pathogenesis and progression. The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to...

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Autores principales: Chorąży, Monika, Wawrusiewicz-Kurylonek, Natalia, Adamska-Patruno, Edyta, Zajkowska, Olga, Kapica-Topczewska, Katarzyna, Posmyk, Renata, Krętowski, Adam Jacek, Kochanowicz, Jan, Kułakowska, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673932/
https://www.ncbi.nlm.nih.gov/pubmed/33224992
http://dx.doi.org/10.1155/2020/8838014
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author Chorąży, Monika
Wawrusiewicz-Kurylonek, Natalia
Adamska-Patruno, Edyta
Zajkowska, Olga
Kapica-Topczewska, Katarzyna
Posmyk, Renata
Krętowski, Adam Jacek
Kochanowicz, Jan
Kułakowska, Alina
author_facet Chorąży, Monika
Wawrusiewicz-Kurylonek, Natalia
Adamska-Patruno, Edyta
Zajkowska, Olga
Kapica-Topczewska, Katarzyna
Posmyk, Renata
Krętowski, Adam Jacek
Kochanowicz, Jan
Kułakowska, Alina
author_sort Chorąży, Monika
collection PubMed
description PURPOSE: Multiple sclerosis (MS) is an autoimmune disease, and genetic factors play an important role in its pathogenesis and progression. The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability. METHODS: 94 subjects with MS and 160 healthy individuals have been genotyped for seven common single-nucleotide variants in IL-2RA, CTLA4, CD40, and PADI4 genes. The ages of onset, duration of the disease, and clinical condition of the MS subjects were analysed. We used the Chi(2) test confirmed with Fisher's exact test for statistical analysis. RESULTS: The frequency of allele T and CT/TT genotypes (rs7093069) in the IL2RA gene, as well as the T allele and CT/TT genotypes in rs12722598, were significantly higher in the control group. The significant differences between studied groups we also found for the G allele and GG/GA genotypes of rs3087243 in CTLA4 gene, which were more common among the control group. The heterozygous genotype TC (rs1883832) of CD40 gene was more common in the control subjects, and the frequency of the alleles and genotypes in the rs1748033 of the PADI4 gene did not differ between the studied groups. Between the studied genotypes, we did not observe any significant differences in the age of onset and duration of disease, including sex stratification. CONCLUSION: Our results highlight the protective role of some of the T-cell homeostasis-related genetic variants in MS development, but not in its clinical manifestation.
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spelling pubmed-76739322020-11-19 Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population Chorąży, Monika Wawrusiewicz-Kurylonek, Natalia Adamska-Patruno, Edyta Zajkowska, Olga Kapica-Topczewska, Katarzyna Posmyk, Renata Krętowski, Adam Jacek Kochanowicz, Jan Kułakowska, Alina J Immunol Res Research Article PURPOSE: Multiple sclerosis (MS) is an autoimmune disease, and genetic factors play an important role in its pathogenesis and progression. The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability. METHODS: 94 subjects with MS and 160 healthy individuals have been genotyped for seven common single-nucleotide variants in IL-2RA, CTLA4, CD40, and PADI4 genes. The ages of onset, duration of the disease, and clinical condition of the MS subjects were analysed. We used the Chi(2) test confirmed with Fisher's exact test for statistical analysis. RESULTS: The frequency of allele T and CT/TT genotypes (rs7093069) in the IL2RA gene, as well as the T allele and CT/TT genotypes in rs12722598, were significantly higher in the control group. The significant differences between studied groups we also found for the G allele and GG/GA genotypes of rs3087243 in CTLA4 gene, which were more common among the control group. The heterozygous genotype TC (rs1883832) of CD40 gene was more common in the control subjects, and the frequency of the alleles and genotypes in the rs1748033 of the PADI4 gene did not differ between the studied groups. Between the studied genotypes, we did not observe any significant differences in the age of onset and duration of disease, including sex stratification. CONCLUSION: Our results highlight the protective role of some of the T-cell homeostasis-related genetic variants in MS development, but not in its clinical manifestation. Hindawi 2020-11-11 /pmc/articles/PMC7673932/ /pubmed/33224992 http://dx.doi.org/10.1155/2020/8838014 Text en Copyright © 2020 Monika Chorąży et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chorąży, Monika
Wawrusiewicz-Kurylonek, Natalia
Adamska-Patruno, Edyta
Zajkowska, Olga
Kapica-Topczewska, Katarzyna
Posmyk, Renata
Krętowski, Adam Jacek
Kochanowicz, Jan
Kułakowska, Alina
Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
title Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
title_full Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
title_fullStr Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
title_full_unstemmed Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
title_short Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population
title_sort some common snps of the t-cell homeostasis-related genes are associated with multiple sclerosis, but not with the clinical manifestations of the disease, in the polish population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673932/
https://www.ncbi.nlm.nih.gov/pubmed/33224992
http://dx.doi.org/10.1155/2020/8838014
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