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Increased choroidal thickness is not a disease progression marker in keratoconus

The recent findings of increased Choroidal Thickness (CT) in Keratoconus (KC) patients raised the question of whether CT could be an indicator of progressive KC. To test this hypothesis, we evaluated and compared the choroidal profile in progressive and non-progressive KC. We ran a cross-sectional o...

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Autores principales: Pinheiro-Costa, João, Correia, Paulo Jorge, Pinto, João Viana, Alves, Hélio, Torrão, Luís, Moreira, Raul, Falcão, Manuel, Carneiro, Ângela, Madeira, Maria Dulce, Falcão-Reis, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673983/
https://www.ncbi.nlm.nih.gov/pubmed/33203915
http://dx.doi.org/10.1038/s41598-020-77122-x
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author Pinheiro-Costa, João
Correia, Paulo Jorge
Pinto, João Viana
Alves, Hélio
Torrão, Luís
Moreira, Raul
Falcão, Manuel
Carneiro, Ângela
Madeira, Maria Dulce
Falcão-Reis, Fernando
author_facet Pinheiro-Costa, João
Correia, Paulo Jorge
Pinto, João Viana
Alves, Hélio
Torrão, Luís
Moreira, Raul
Falcão, Manuel
Carneiro, Ângela
Madeira, Maria Dulce
Falcão-Reis, Fernando
author_sort Pinheiro-Costa, João
collection PubMed
description The recent findings of increased Choroidal Thickness (CT) in Keratoconus (KC) patients raised the question of whether CT could be an indicator of progressive KC. To test this hypothesis, we evaluated and compared the choroidal profile in progressive and non-progressive KC. We ran a cross-sectional observational study in 76 patients diagnosed with KC, age 14–30, to assess KC progression. Progression was defined as when at least two of the studied variables confirmed progression (Kmax, Km, PachyMin, D-Index, Astig, K2, 3 mm PCR). Included patients performed a Spectralis Optical Coherence Tomography (OCT) with enhanced depth image (EDI) technology to evaluate choroidal profile. Choroidal measurements were taken subfoveally and at 500 µm intervals from the fovea, in 7 different locations, and compared between groups. Multivariate linear regression analyses were also performed to assess the influence of CT in KC progression. Thirty-six eyes (47.4%) were classified as KC progressors. The mean subfoveal CT observed in the total sample was 382.0 (± 97.0) μm. The comparison between groups (progressive and non-progressive KC) showed no differences in the locations evaluated (mean subfoveal CT difference between groups was 2.4 μm, p = 0.915). In the multivariate analysis CT seems not be influenced by KC progression (B = 6.72 μm, 95% CI − 40.09 to 53.53, p = 0.775). Assessment of choroidal profile does not appear to be a useful tool to differentiate progressive and non-progressive KC. Further research is needed in order to better understand the role of choroid in KC.
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spelling pubmed-76739832020-11-19 Increased choroidal thickness is not a disease progression marker in keratoconus Pinheiro-Costa, João Correia, Paulo Jorge Pinto, João Viana Alves, Hélio Torrão, Luís Moreira, Raul Falcão, Manuel Carneiro, Ângela Madeira, Maria Dulce Falcão-Reis, Fernando Sci Rep Article The recent findings of increased Choroidal Thickness (CT) in Keratoconus (KC) patients raised the question of whether CT could be an indicator of progressive KC. To test this hypothesis, we evaluated and compared the choroidal profile in progressive and non-progressive KC. We ran a cross-sectional observational study in 76 patients diagnosed with KC, age 14–30, to assess KC progression. Progression was defined as when at least two of the studied variables confirmed progression (Kmax, Km, PachyMin, D-Index, Astig, K2, 3 mm PCR). Included patients performed a Spectralis Optical Coherence Tomography (OCT) with enhanced depth image (EDI) technology to evaluate choroidal profile. Choroidal measurements were taken subfoveally and at 500 µm intervals from the fovea, in 7 different locations, and compared between groups. Multivariate linear regression analyses were also performed to assess the influence of CT in KC progression. Thirty-six eyes (47.4%) were classified as KC progressors. The mean subfoveal CT observed in the total sample was 382.0 (± 97.0) μm. The comparison between groups (progressive and non-progressive KC) showed no differences in the locations evaluated (mean subfoveal CT difference between groups was 2.4 μm, p = 0.915). In the multivariate analysis CT seems not be influenced by KC progression (B = 6.72 μm, 95% CI − 40.09 to 53.53, p = 0.775). Assessment of choroidal profile does not appear to be a useful tool to differentiate progressive and non-progressive KC. Further research is needed in order to better understand the role of choroid in KC. Nature Publishing Group UK 2020-11-17 /pmc/articles/PMC7673983/ /pubmed/33203915 http://dx.doi.org/10.1038/s41598-020-77122-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pinheiro-Costa, João
Correia, Paulo Jorge
Pinto, João Viana
Alves, Hélio
Torrão, Luís
Moreira, Raul
Falcão, Manuel
Carneiro, Ângela
Madeira, Maria Dulce
Falcão-Reis, Fernando
Increased choroidal thickness is not a disease progression marker in keratoconus
title Increased choroidal thickness is not a disease progression marker in keratoconus
title_full Increased choroidal thickness is not a disease progression marker in keratoconus
title_fullStr Increased choroidal thickness is not a disease progression marker in keratoconus
title_full_unstemmed Increased choroidal thickness is not a disease progression marker in keratoconus
title_short Increased choroidal thickness is not a disease progression marker in keratoconus
title_sort increased choroidal thickness is not a disease progression marker in keratoconus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673983/
https://www.ncbi.nlm.nih.gov/pubmed/33203915
http://dx.doi.org/10.1038/s41598-020-77122-x
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