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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genom...

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Autores principales: Volz, Erik, Hill, Verity, McCrone, John T., Price, Anna, Jorgensen, David, O’Toole, Áine, Southgate, Joel, Johnson, Robert, Jackson, Ben, Nascimento, Fabricia F., Rey, Sara M., Nicholls, Samuel M., Colquhoun, Rachel M., da Silva Filipe, Ana, Shepherd, James, Pascall, David J., Shah, Rajiv, Jesudason, Natasha, Li, Kathy, Jarrett, Ruth, Pacchiarini, Nicole, Bull, Matthew, Geidelberg, Lily, Siveroni, Igor, Goodfellow, Ian, Loman, Nicholas J., Pybus, Oliver G., Robertson, David L., Thomson, Emma C., Rambaut, Andrew, Connor, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674007/
https://www.ncbi.nlm.nih.gov/pubmed/33275900
http://dx.doi.org/10.1016/j.cell.2020.11.020
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author Volz, Erik
Hill, Verity
McCrone, John T.
Price, Anna
Jorgensen, David
O’Toole, Áine
Southgate, Joel
Johnson, Robert
Jackson, Ben
Nascimento, Fabricia F.
Rey, Sara M.
Nicholls, Samuel M.
Colquhoun, Rachel M.
da Silva Filipe, Ana
Shepherd, James
Pascall, David J.
Shah, Rajiv
Jesudason, Natasha
Li, Kathy
Jarrett, Ruth
Pacchiarini, Nicole
Bull, Matthew
Geidelberg, Lily
Siveroni, Igor
Goodfellow, Ian
Loman, Nicholas J.
Pybus, Oliver G.
Robertson, David L.
Thomson, Emma C.
Rambaut, Andrew
Connor, Thomas R.
author_facet Volz, Erik
Hill, Verity
McCrone, John T.
Price, Anna
Jorgensen, David
O’Toole, Áine
Southgate, Joel
Johnson, Robert
Jackson, Ben
Nascimento, Fabricia F.
Rey, Sara M.
Nicholls, Samuel M.
Colquhoun, Rachel M.
da Silva Filipe, Ana
Shepherd, James
Pascall, David J.
Shah, Rajiv
Jesudason, Natasha
Li, Kathy
Jarrett, Ruth
Pacchiarini, Nicole
Bull, Matthew
Geidelberg, Lily
Siveroni, Igor
Goodfellow, Ian
Loman, Nicholas J.
Pybus, Oliver G.
Robertson, David L.
Thomson, Emma C.
Rambaut, Andrew
Connor, Thomas R.
author_sort Volz, Erik
collection PubMed
description Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
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spelling pubmed-76740072020-11-19 Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity Volz, Erik Hill, Verity McCrone, John T. Price, Anna Jorgensen, David O’Toole, Áine Southgate, Joel Johnson, Robert Jackson, Ben Nascimento, Fabricia F. Rey, Sara M. Nicholls, Samuel M. Colquhoun, Rachel M. da Silva Filipe, Ana Shepherd, James Pascall, David J. Shah, Rajiv Jesudason, Natasha Li, Kathy Jarrett, Ruth Pacchiarini, Nicole Bull, Matthew Geidelberg, Lily Siveroni, Igor Goodfellow, Ian Loman, Nicholas J. Pybus, Oliver G. Robertson, David L. Thomson, Emma C. Rambaut, Andrew Connor, Thomas R. Cell Article Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant. Cell Press 2021-01-07 /pmc/articles/PMC7674007/ /pubmed/33275900 http://dx.doi.org/10.1016/j.cell.2020.11.020 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Volz, Erik
Hill, Verity
McCrone, John T.
Price, Anna
Jorgensen, David
O’Toole, Áine
Southgate, Joel
Johnson, Robert
Jackson, Ben
Nascimento, Fabricia F.
Rey, Sara M.
Nicholls, Samuel M.
Colquhoun, Rachel M.
da Silva Filipe, Ana
Shepherd, James
Pascall, David J.
Shah, Rajiv
Jesudason, Natasha
Li, Kathy
Jarrett, Ruth
Pacchiarini, Nicole
Bull, Matthew
Geidelberg, Lily
Siveroni, Igor
Goodfellow, Ian
Loman, Nicholas J.
Pybus, Oliver G.
Robertson, David L.
Thomson, Emma C.
Rambaut, Andrew
Connor, Thomas R.
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
title Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
title_full Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
title_fullStr Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
title_full_unstemmed Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
title_short Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
title_sort evaluating the effects of sars-cov-2 spike mutation d614g on transmissibility and pathogenicity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674007/
https://www.ncbi.nlm.nih.gov/pubmed/33275900
http://dx.doi.org/10.1016/j.cell.2020.11.020
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