Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute lung damage associated with patient mortality. While multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we found that only the combination of TNF-α and IFN-γ induce...

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Detalles Bibliográficos
Autores principales: Karki, Rajendra, Sharma, Bhesh Raj, Tuladhar, Shraddha, Williams, Evan Peter, Zalduondo, Lillian, Samir, Parimal, Zheng, Min, Sundaram, Balamurugan, Banoth, Balaji, Malireddi, R.K. Subbarao, Schreiner, Patrick, Neale, Geoffrey, Vogel, Peter, Webby, Richard, Jonsson, Colleen Beth, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674074/
https://www.ncbi.nlm.nih.gov/pubmed/33278357
http://dx.doi.org/10.1016/j.cell.2020.11.025
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