Cargando…

Post-translational Modifications of IκBα: The State of the Art

The nuclear factor-kappa B (NF-κB) signaling pathway regulates a variety of biological functions in the body, and its abnormal activation contributes to the pathogenesis of many diseases, such as cardiovascular and respiratory diseases and cancers. Therefore, to ensure physiological homeostasis of b...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiuli, Peng, Hanlin, Huang, Yaqian, Kong, Wei, Cui, Qinghua, Du, Junbao, Jin, Hongfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674170/
https://www.ncbi.nlm.nih.gov/pubmed/33224945
http://dx.doi.org/10.3389/fcell.2020.574706
_version_ 1783611462583844864
author Wang, Xiuli
Peng, Hanlin
Huang, Yaqian
Kong, Wei
Cui, Qinghua
Du, Junbao
Jin, Hongfang
author_facet Wang, Xiuli
Peng, Hanlin
Huang, Yaqian
Kong, Wei
Cui, Qinghua
Du, Junbao
Jin, Hongfang
author_sort Wang, Xiuli
collection PubMed
description The nuclear factor-kappa B (NF-κB) signaling pathway regulates a variety of biological functions in the body, and its abnormal activation contributes to the pathogenesis of many diseases, such as cardiovascular and respiratory diseases and cancers. Therefore, to ensure physiological homeostasis of body systems, this pathway is strictly regulated by IκBα transcription, IκBα synthesis, and the IκBα-dependent nuclear transport of NF-κB. Particularly, the post-translational modifications of IκBα including phosphorylation, ubiquitination, SUMOylation, glutathionylation and hydroxylation are crucial in the abovementioned regulatory process. Because of the importance of the NF-κB pathway in maintaining body homeostasis, understanding the post-translational modifications of IκBα can not only provide deeper insights into the regulation of NF-κB pathway but also contribute to the development of new drug targets and biomarkers for the diseases.
format Online
Article
Text
id pubmed-7674170
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-76741702020-11-19 Post-translational Modifications of IκBα: The State of the Art Wang, Xiuli Peng, Hanlin Huang, Yaqian Kong, Wei Cui, Qinghua Du, Junbao Jin, Hongfang Front Cell Dev Biol Cell and Developmental Biology The nuclear factor-kappa B (NF-κB) signaling pathway regulates a variety of biological functions in the body, and its abnormal activation contributes to the pathogenesis of many diseases, such as cardiovascular and respiratory diseases and cancers. Therefore, to ensure physiological homeostasis of body systems, this pathway is strictly regulated by IκBα transcription, IκBα synthesis, and the IκBα-dependent nuclear transport of NF-κB. Particularly, the post-translational modifications of IκBα including phosphorylation, ubiquitination, SUMOylation, glutathionylation and hydroxylation are crucial in the abovementioned regulatory process. Because of the importance of the NF-κB pathway in maintaining body homeostasis, understanding the post-translational modifications of IκBα can not only provide deeper insights into the regulation of NF-κB pathway but also contribute to the development of new drug targets and biomarkers for the diseases. Frontiers Media S.A. 2020-11-05 /pmc/articles/PMC7674170/ /pubmed/33224945 http://dx.doi.org/10.3389/fcell.2020.574706 Text en Copyright © 2020 Wang, Peng, Huang, Kong, Cui, Du and Jin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Xiuli
Peng, Hanlin
Huang, Yaqian
Kong, Wei
Cui, Qinghua
Du, Junbao
Jin, Hongfang
Post-translational Modifications of IκBα: The State of the Art
title Post-translational Modifications of IκBα: The State of the Art
title_full Post-translational Modifications of IκBα: The State of the Art
title_fullStr Post-translational Modifications of IκBα: The State of the Art
title_full_unstemmed Post-translational Modifications of IκBα: The State of the Art
title_short Post-translational Modifications of IκBα: The State of the Art
title_sort post-translational modifications of iκbα: the state of the art
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674170/
https://www.ncbi.nlm.nih.gov/pubmed/33224945
http://dx.doi.org/10.3389/fcell.2020.574706
work_keys_str_mv AT wangxiuli posttranslationalmodificationsofikbathestateoftheart
AT penghanlin posttranslationalmodificationsofikbathestateoftheart
AT huangyaqian posttranslationalmodificationsofikbathestateoftheart
AT kongwei posttranslationalmodificationsofikbathestateoftheart
AT cuiqinghua posttranslationalmodificationsofikbathestateoftheart
AT dujunbao posttranslationalmodificationsofikbathestateoftheart
AT jinhongfang posttranslationalmodificationsofikbathestateoftheart