Cargando…
The HIF1α/HIF2α-miR210-3p network regulates glioblastoma cell proliferation, dedifferentiation and chemoresistance through EGF under hypoxic conditions
Hypoxia-inducible factor 1α (HIF1α) promotes the malignant progression of glioblastoma under hypoxic conditions, leading to a poor prognosis for patients with glioblastoma; however, none of the therapies targeting HIF1α in glioblastoma have successfully eradicated the tumour. Therefore, we focused o...
Autores principales: | Wang, Pan, Yan, Qian, Liao, Bin, Zhao, Lu, Xiong, Shuanglong, Wang, Junwei, Zou, Dewei, Pan, Jinyu, Wu, Liangqi, Deng, Yangmin, Wu, Nan, Gong, Sheng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674439/ https://www.ncbi.nlm.nih.gov/pubmed/33208727 http://dx.doi.org/10.1038/s41419-020-03150-0 |
Ejemplares similares
-
HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
por: Wang, Pan, et al.
Publicado: (2022) -
HIF1α/HIF2α–Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR–PI3K/AKT signalling pathway with positive feedback under hypoxia
por: Wang, Pan, et al.
Publicado: (2021) -
Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2
por: Wang, Pan, et al.
Publicado: (2021) -
HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
por: Wang, Pan, et al.
Publicado: (2017) -
HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia
por: Wang, Pan, et al.
Publicado: (2017)