Effect of pH on the influenza fusion peptide properties unveiled by constant-pH molecular dynamics simulations combined with experiment

The influenza virus fusion process, whereby the virus fuses its envelope with the host endosome membrane to release the genetic material, takes place in the acidic late endosome environment. Acidification triggers a large conformational change in the fusion protein, hemagglutinin (HA), which enables...

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Detalles Bibliográficos
Autores principales: Lousa, Diana, Pinto, Antónia R. T., Campos, Sara R. R., Baptista, António M., Veiga, Ana S., Castanho, Miguel A. R. B., Soares, Cláudio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674464/
https://www.ncbi.nlm.nih.gov/pubmed/33208852
http://dx.doi.org/10.1038/s41598-020-77040-y

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