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Genome-enabled discovery of anthraquinone biosynthesis in Senna tora

Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the ch...

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Detalles Bibliográficos
Autores principales: Kang, Sang-Ho, Pandey, Ramesh Prasad, Lee, Chang-Muk, Sim, Joon-Soo, Jeong, Jin-Tae, Choi, Beom-Soon, Jung, Myunghee, Ginzburg, Daniel, Zhao, Kangmei, Won, So Youn, Oh, Tae-Jin, Yu, Yeisoo, Kim, Nam-Hoon, Lee, Ok Ran, Lee, Tae-Ho, Bashyal, Puspalata, Kim, Tae-Su, Lee, Woo-Haeng, Hawkins, Charles, Kim, Chang-Kug, Kim, Jung Sun, Ahn, Byoung Ohg, Rhee, Seung Yon, Sohng, Jae Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674472/
https://www.ncbi.nlm.nih.gov/pubmed/33208749
http://dx.doi.org/10.1038/s41467-020-19681-1
Descripción
Sumario:Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.