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Genome-enabled discovery of anthraquinone biosynthesis in Senna tora

Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the ch...

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Autores principales: Kang, Sang-Ho, Pandey, Ramesh Prasad, Lee, Chang-Muk, Sim, Joon-Soo, Jeong, Jin-Tae, Choi, Beom-Soon, Jung, Myunghee, Ginzburg, Daniel, Zhao, Kangmei, Won, So Youn, Oh, Tae-Jin, Yu, Yeisoo, Kim, Nam-Hoon, Lee, Ok Ran, Lee, Tae-Ho, Bashyal, Puspalata, Kim, Tae-Su, Lee, Woo-Haeng, Hawkins, Charles, Kim, Chang-Kug, Kim, Jung Sun, Ahn, Byoung Ohg, Rhee, Seung Yon, Sohng, Jae Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674472/
https://www.ncbi.nlm.nih.gov/pubmed/33208749
http://dx.doi.org/10.1038/s41467-020-19681-1
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author Kang, Sang-Ho
Pandey, Ramesh Prasad
Lee, Chang-Muk
Sim, Joon-Soo
Jeong, Jin-Tae
Choi, Beom-Soon
Jung, Myunghee
Ginzburg, Daniel
Zhao, Kangmei
Won, So Youn
Oh, Tae-Jin
Yu, Yeisoo
Kim, Nam-Hoon
Lee, Ok Ran
Lee, Tae-Ho
Bashyal, Puspalata
Kim, Tae-Su
Lee, Woo-Haeng
Hawkins, Charles
Kim, Chang-Kug
Kim, Jung Sun
Ahn, Byoung Ohg
Rhee, Seung Yon
Sohng, Jae Kyung
author_facet Kang, Sang-Ho
Pandey, Ramesh Prasad
Lee, Chang-Muk
Sim, Joon-Soo
Jeong, Jin-Tae
Choi, Beom-Soon
Jung, Myunghee
Ginzburg, Daniel
Zhao, Kangmei
Won, So Youn
Oh, Tae-Jin
Yu, Yeisoo
Kim, Nam-Hoon
Lee, Ok Ran
Lee, Tae-Ho
Bashyal, Puspalata
Kim, Tae-Su
Lee, Woo-Haeng
Hawkins, Charles
Kim, Chang-Kug
Kim, Jung Sun
Ahn, Byoung Ohg
Rhee, Seung Yon
Sohng, Jae Kyung
author_sort Kang, Sang-Ho
collection PubMed
description Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.
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spelling pubmed-76744722020-11-24 Genome-enabled discovery of anthraquinone biosynthesis in Senna tora Kang, Sang-Ho Pandey, Ramesh Prasad Lee, Chang-Muk Sim, Joon-Soo Jeong, Jin-Tae Choi, Beom-Soon Jung, Myunghee Ginzburg, Daniel Zhao, Kangmei Won, So Youn Oh, Tae-Jin Yu, Yeisoo Kim, Nam-Hoon Lee, Ok Ran Lee, Tae-Ho Bashyal, Puspalata Kim, Tae-Su Lee, Woo-Haeng Hawkins, Charles Kim, Chang-Kug Kim, Jung Sun Ahn, Byoung Ohg Rhee, Seung Yon Sohng, Jae Kyung Nat Commun Article Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants. Nature Publishing Group UK 2020-11-18 /pmc/articles/PMC7674472/ /pubmed/33208749 http://dx.doi.org/10.1038/s41467-020-19681-1 Text en © The Author(s) 2020, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kang, Sang-Ho
Pandey, Ramesh Prasad
Lee, Chang-Muk
Sim, Joon-Soo
Jeong, Jin-Tae
Choi, Beom-Soon
Jung, Myunghee
Ginzburg, Daniel
Zhao, Kangmei
Won, So Youn
Oh, Tae-Jin
Yu, Yeisoo
Kim, Nam-Hoon
Lee, Ok Ran
Lee, Tae-Ho
Bashyal, Puspalata
Kim, Tae-Su
Lee, Woo-Haeng
Hawkins, Charles
Kim, Chang-Kug
Kim, Jung Sun
Ahn, Byoung Ohg
Rhee, Seung Yon
Sohng, Jae Kyung
Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
title Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
title_full Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
title_fullStr Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
title_full_unstemmed Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
title_short Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
title_sort genome-enabled discovery of anthraquinone biosynthesis in senna tora
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674472/
https://www.ncbi.nlm.nih.gov/pubmed/33208749
http://dx.doi.org/10.1038/s41467-020-19681-1
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