Experimental sleep disruption attenuates morphine analgesia: findings from a randomized trial and implications for the opioid abuse epidemic

Preclinical studies demonstrate that sleep disruption diminishes morphine analgesia and modulates reward processing. We sought to translate these preclinical findings to humans by examining whether sleep disruption alters morphine’s analgesic and hedonic properties. We randomized 100 healthy adults...

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Detalles Bibliográficos
Autores principales: Smith, Michael T., Mun, Chung Jung, Remeniuk, Bethany, Finan, Patrick H., Campbell, Claudia M., Buenaver, Luis F., Robinson, Mercedes, Fulton, Brook, Tompkins, David Andrew, Tremblay, Jean-Michel, Strain, Eric C., Irwin, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674501/
https://www.ncbi.nlm.nih.gov/pubmed/33208831
http://dx.doi.org/10.1038/s41598-020-76934-1

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