Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin

BACKGROUND AND AIMS: Characterization of cell specific transcriptional responses to hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single-cell/nuclei RNA-seq technologies enable the transcriptomes of individual cell (sub)types to be assessed within the context of in vivo m...

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Detalles Bibliográficos
Autores principales: Nault, Rance, Fader, Kelly A., Bhattacharya, Sudin, Zacharewski, Tim R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674514/
https://www.ncbi.nlm.nih.gov/pubmed/32791302
http://dx.doi.org/10.1016/j.jcmgh.2020.07.012

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