Rationale and design of the Medical Research Council's Precision Medicine with Zibotentan in Microvascular Angina (PRIZE) trial

Microvascular angina is caused by cardiac small vessel disease, and dysregulation of the endothelin system is implicated. The minor G allele of the non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression of the endothelin 1 gene in human vascular cells, increasing circulating c...

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Detalles Bibliográficos
Autores principales: Morrow, Andrew J, Ford, Thomas J, Mangion, Kenneth, Kotecha, Tushar, Rakhit, Roby, Galasko, Gavin, Hoole, Stephen, Davenport, Anthony, Kharbanda, Rajesh, Ferreira, Vanessa M, Shanmuganathan, Mayooran, Chiribiri, Amedeo, Perera, Divaka, Rahman, Haseeb, Arnold, Jayanth R., Greenwood, John P., Fisher, Michael, Husmeier, Dirk, Hill, Nicholas A, Luo, Xiaoyu, Williams, Nicola, Miller, Laura, Dempster, Jill, Macfarlane, Peter W, Welsh, Paul, Sattar, Naveed, Whittaker, Andrew, Connachie, Alex Mc, Padmanabhan, Sandosh, Berry, Colin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2020
Materias:
Trial Design
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674581/
https://www.ncbi.nlm.nih.gov/pubmed/32942043
http://dx.doi.org/10.1016/j.ahj.2020.07.007

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