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Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy
Methods to evaluate the positional reproducibility of breath-hold irradiation mostly require manual operation. The purpose of this study is to propose a method to determine the reproducibility of breath-hold irradiation of lung tumors between fractions using non-artificial methods. This study includ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674682/ https://www.ncbi.nlm.nih.gov/pubmed/32930802 http://dx.doi.org/10.1093/jrr/rraa079 |
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author | Sasaki, Motoharu Ikushima, Hitoshi Sakuragawa, Kanako Yokoishi, Michihiro Tsuzuki, Akira Sugimoto, Wataru |
author_facet | Sasaki, Motoharu Ikushima, Hitoshi Sakuragawa, Kanako Yokoishi, Michihiro Tsuzuki, Akira Sugimoto, Wataru |
author_sort | Sasaki, Motoharu |
collection | PubMed |
description | Methods to evaluate the positional reproducibility of breath-hold irradiation mostly require manual operation. The purpose of this study is to propose a method to determine the reproducibility of breath-hold irradiation of lung tumors between fractions using non-artificial methods. This study included 13 patients who underwent terminal exhaled breath-hold irradiation for primary and metastatic lung cancer. All subjects received a prescribed dose of 60 Gy/8 fractions. The contours of the gross tumor volume (GTV) were extracted by threshold processing using treatment-planning computed tomography (CT) and cone-beam CT (CBCT), which was done just before the beginning of the treatment. The method proposed in this study evaluates the dice similarity coefficient (DSC) and Hausdorff distance (HD) by comparing two volumes, the GTV(CTS) (GTV obtained from treatment-planning CT) and GTV(CBCT) (GTV obtained from CBCT). The reference contours for DSC and HD are represented by GTV(CTS). The results demonstrated good visual agreement for cases with a DSC of ~0.7. However, apparent misalignment occurred when the DSC was <0.5. HD was >2 mm in 3 out of 13 cases, and when the DSC was ~0.7, the HD was ~1 mm. In addition, cases with greater HD also demonstrated more significant variability. It was found that the DSC and HD evaluation methods for the positional reproducibility of breath-hold irradiation proposed in this study are straightforward and can be performed without the involvement of humans. Our study is of extreme significance in the field of radiation studies. |
format | Online Article Text |
id | pubmed-7674682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-76746822020-11-24 Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy Sasaki, Motoharu Ikushima, Hitoshi Sakuragawa, Kanako Yokoishi, Michihiro Tsuzuki, Akira Sugimoto, Wataru J Radiat Res Oncology/Medicine Methods to evaluate the positional reproducibility of breath-hold irradiation mostly require manual operation. The purpose of this study is to propose a method to determine the reproducibility of breath-hold irradiation of lung tumors between fractions using non-artificial methods. This study included 13 patients who underwent terminal exhaled breath-hold irradiation for primary and metastatic lung cancer. All subjects received a prescribed dose of 60 Gy/8 fractions. The contours of the gross tumor volume (GTV) were extracted by threshold processing using treatment-planning computed tomography (CT) and cone-beam CT (CBCT), which was done just before the beginning of the treatment. The method proposed in this study evaluates the dice similarity coefficient (DSC) and Hausdorff distance (HD) by comparing two volumes, the GTV(CTS) (GTV obtained from treatment-planning CT) and GTV(CBCT) (GTV obtained from CBCT). The reference contours for DSC and HD are represented by GTV(CTS). The results demonstrated good visual agreement for cases with a DSC of ~0.7. However, apparent misalignment occurred when the DSC was <0.5. HD was >2 mm in 3 out of 13 cases, and when the DSC was ~0.7, the HD was ~1 mm. In addition, cases with greater HD also demonstrated more significant variability. It was found that the DSC and HD evaluation methods for the positional reproducibility of breath-hold irradiation proposed in this study are straightforward and can be performed without the involvement of humans. Our study is of extreme significance in the field of radiation studies. Oxford University Press 2020-09-15 /pmc/articles/PMC7674682/ /pubmed/32930802 http://dx.doi.org/10.1093/jrr/rraa079 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Oncology/Medicine Sasaki, Motoharu Ikushima, Hitoshi Sakuragawa, Kanako Yokoishi, Michihiro Tsuzuki, Akira Sugimoto, Wataru Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
title | Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
title_full | Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
title_fullStr | Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
title_full_unstemmed | Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
title_short | Determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
title_sort | determination of reproducibility of end-exhaled breath-holding in stereotactic body radiation therapy |
topic | Oncology/Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674682/ https://www.ncbi.nlm.nih.gov/pubmed/32930802 http://dx.doi.org/10.1093/jrr/rraa079 |
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