Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease

Alzheimer’s disease (AD) is an incurable neurodegenerative disease. Numerous studies have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis. In this review, we summarize metabolic alterations in aging brain and AD-related metabolic deficits associated with glucose...

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Autores principales: Yan, Xu, Hu, Yue, Wang, Biyao, Wang, Sijian, Zhang, Xinwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674854/
https://www.ncbi.nlm.nih.gov/pubmed/33250703
http://dx.doi.org/10.3389/fnins.2020.530219
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author Yan, Xu
Hu, Yue
Wang, Biyao
Wang, Sijian
Zhang, Xinwen
author_facet Yan, Xu
Hu, Yue
Wang, Biyao
Wang, Sijian
Zhang, Xinwen
author_sort Yan, Xu
collection PubMed
description Alzheimer’s disease (AD) is an incurable neurodegenerative disease. Numerous studies have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis. In this review, we summarize metabolic alterations in aging brain and AD-related metabolic deficits associated with glucose metabolism dysregulation, glycolysis dysfunction, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS) deficits, and pentose phosphate pathway impairment. Additionally, we discuss recent treatment strategies targeting metabolic defects in AD, including their limitations, in an effort to encourage the development of novel therapeutic strategies.
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spelling pubmed-76748542020-11-26 Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease Yan, Xu Hu, Yue Wang, Biyao Wang, Sijian Zhang, Xinwen Front Neurosci Neuroscience Alzheimer’s disease (AD) is an incurable neurodegenerative disease. Numerous studies have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis. In this review, we summarize metabolic alterations in aging brain and AD-related metabolic deficits associated with glucose metabolism dysregulation, glycolysis dysfunction, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS) deficits, and pentose phosphate pathway impairment. Additionally, we discuss recent treatment strategies targeting metabolic defects in AD, including their limitations, in an effort to encourage the development of novel therapeutic strategies. Frontiers Media S.A. 2020-11-05 /pmc/articles/PMC7674854/ /pubmed/33250703 http://dx.doi.org/10.3389/fnins.2020.530219 Text en Copyright © 2020 Yan, Hu, Wang, Wang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yan, Xu
Hu, Yue
Wang, Biyao
Wang, Sijian
Zhang, Xinwen
Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
title Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
title_full Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
title_fullStr Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
title_full_unstemmed Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
title_short Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
title_sort metabolic dysregulation contributes to the progression of alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674854/
https://www.ncbi.nlm.nih.gov/pubmed/33250703
http://dx.doi.org/10.3389/fnins.2020.530219
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