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Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
OBJECTIVE: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. METHODS: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and obser...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674911/ https://www.ncbi.nlm.nih.gov/pubmed/33235598 http://dx.doi.org/10.12669/pjms.36.7.2018 |
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author | Dai, Xiaoxia Feng, Tao Zhang, Xuejuan Li, Kaishu |
author_facet | Dai, Xiaoxia Feng, Tao Zhang, Xuejuan Li, Kaishu |
author_sort | Dai, Xiaoxia |
collection | PubMed |
description | OBJECTIVE: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. METHODS: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared. RESULTS: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05). CONCLUSION: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application. |
format | Online Article Text |
id | pubmed-7674911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-76749112020-11-23 Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma Dai, Xiaoxia Feng, Tao Zhang, Xuejuan Li, Kaishu Pak J Med Sci Original Article OBJECTIVE: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. METHODS: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared. RESULTS: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05). CONCLUSION: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application. Professional Medical Publications 2020 /pmc/articles/PMC7674911/ /pubmed/33235598 http://dx.doi.org/10.12669/pjms.36.7.2018 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dai, Xiaoxia Feng, Tao Zhang, Xuejuan Li, Kaishu Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma |
title | Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma |
title_full | Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma |
title_fullStr | Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma |
title_full_unstemmed | Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma |
title_short | Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma |
title_sort | budesonide/fomoterol in combination with montelukast in the treatment of bronchial asthma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674911/ https://www.ncbi.nlm.nih.gov/pubmed/33235598 http://dx.doi.org/10.12669/pjms.36.7.2018 |
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