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Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma

OBJECTIVE: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. METHODS: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and obser...

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Autores principales: Dai, Xiaoxia, Feng, Tao, Zhang, Xuejuan, Li, Kaishu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674911/
https://www.ncbi.nlm.nih.gov/pubmed/33235598
http://dx.doi.org/10.12669/pjms.36.7.2018
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author Dai, Xiaoxia
Feng, Tao
Zhang, Xuejuan
Li, Kaishu
author_facet Dai, Xiaoxia
Feng, Tao
Zhang, Xuejuan
Li, Kaishu
author_sort Dai, Xiaoxia
collection PubMed
description OBJECTIVE: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. METHODS: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared. RESULTS: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05). CONCLUSION: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application.
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spelling pubmed-76749112020-11-23 Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma Dai, Xiaoxia Feng, Tao Zhang, Xuejuan Li, Kaishu Pak J Med Sci Original Article OBJECTIVE: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. METHODS: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared. RESULTS: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05). CONCLUSION: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application. Professional Medical Publications 2020 /pmc/articles/PMC7674911/ /pubmed/33235598 http://dx.doi.org/10.12669/pjms.36.7.2018 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dai, Xiaoxia
Feng, Tao
Zhang, Xuejuan
Li, Kaishu
Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
title Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
title_full Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
title_fullStr Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
title_full_unstemmed Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
title_short Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma
title_sort budesonide/fomoterol in combination with montelukast in the treatment of bronchial asthma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674911/
https://www.ncbi.nlm.nih.gov/pubmed/33235598
http://dx.doi.org/10.12669/pjms.36.7.2018
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