Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development

In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role...

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Autores principales: Zhang, Hong, Lin, Fengping, Zhao, Jiuhua, Wang, Zhengchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674958/
https://www.ncbi.nlm.nih.gov/pubmed/33250784
http://dx.doi.org/10.3389/fphys.2020.595086
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author Zhang, Hong
Lin, Fengping
Zhao, Jiuhua
Wang, Zhengchao
author_facet Zhang, Hong
Lin, Fengping
Zhao, Jiuhua
Wang, Zhengchao
author_sort Zhang, Hong
collection PubMed
description In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology.
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spelling pubmed-76749582020-11-26 Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development Zhang, Hong Lin, Fengping Zhao, Jiuhua Wang, Zhengchao Front Physiol Physiology In mammals, developing ovarian follicles transform from primordial follicles to primary follicles, secondary follicles, and mature follicles, accompanied by changes in follicular secretory functions. FoxO3a is a member of the forkhead transcription factor family (FoxO), which plays an important role in the cell cycle, DNA damage repair, apoptosis, oxidative stress, and energy metabolism. Recent studies have shown that FOXO3a is involved in the physiological regulation of follicular development and pathological progression of related ovarian diseases, which will provide useful concepts and strategies for retarding ovarian aging, prolonging the ovarian life span, and treating ovarian diseases. Therefore, the regulation of FOXO3a expression, as well as the physiological contribution during ovarian follicular development are detailed in this paper, presenting an important reference for the further study of ovarian biology. Frontiers Media S.A. 2020-11-05 /pmc/articles/PMC7674958/ /pubmed/33250784 http://dx.doi.org/10.3389/fphys.2020.595086 Text en Copyright © 2020 Zhang, Lin, Zhao and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhang, Hong
Lin, Fengping
Zhao, Jiuhua
Wang, Zhengchao
Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
title Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
title_full Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
title_fullStr Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
title_full_unstemmed Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
title_short Expression Regulation and Physiological Role of Transcription Factor FOXO3a During Ovarian Follicular Development
title_sort expression regulation and physiological role of transcription factor foxo3a during ovarian follicular development
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674958/
https://www.ncbi.nlm.nih.gov/pubmed/33250784
http://dx.doi.org/10.3389/fphys.2020.595086
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