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White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination
Recent evidence highlighted the importance of white matter tracts in typical and atypical behaviors. White matter dynamically changes in response to learning, stress, and social experiences. Several lines of evidence have reported white matter dysfunction in psychiatric conditions, including depress...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674975/ https://www.ncbi.nlm.nih.gov/pubmed/33250713 http://dx.doi.org/10.3389/fncel.2020.587053 |
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author | Liu, Jia Likhtik, Ekaterina Shereen, A. Duke Dennis-Tiwary, Tracy A. Casaccia, Patrizia |
author_facet | Liu, Jia Likhtik, Ekaterina Shereen, A. Duke Dennis-Tiwary, Tracy A. Casaccia, Patrizia |
author_sort | Liu, Jia |
collection | PubMed |
description | Recent evidence highlighted the importance of white matter tracts in typical and atypical behaviors. White matter dynamically changes in response to learning, stress, and social experiences. Several lines of evidence have reported white matter dysfunction in psychiatric conditions, including depression, stress- and anxiety-related disorders. The mechanistic underpinnings of these associations, however, remain poorly understood. Here, we outline an integrative perspective positing a link between aberrant myelin plasticity and anxiety. Drawing on extant literature and emerging new findings, we suggest that in anxiety, unique changes may occur in response to threat and to safety learning and the ability to discriminate between both types of stimuli. We propose that altered myelin plasticity in the neural circuits underlying these two forms of learning relates to the emergence of anxiety-related disorders, by compromising mechanisms of neural network synchronization. The clinical and translational implications of this model for anxiety-related disorders are discussed. |
format | Online Article Text |
id | pubmed-7674975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76749752020-11-27 White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination Liu, Jia Likhtik, Ekaterina Shereen, A. Duke Dennis-Tiwary, Tracy A. Casaccia, Patrizia Front Cell Neurosci Cellular Neuroscience Recent evidence highlighted the importance of white matter tracts in typical and atypical behaviors. White matter dynamically changes in response to learning, stress, and social experiences. Several lines of evidence have reported white matter dysfunction in psychiatric conditions, including depression, stress- and anxiety-related disorders. The mechanistic underpinnings of these associations, however, remain poorly understood. Here, we outline an integrative perspective positing a link between aberrant myelin plasticity and anxiety. Drawing on extant literature and emerging new findings, we suggest that in anxiety, unique changes may occur in response to threat and to safety learning and the ability to discriminate between both types of stimuli. We propose that altered myelin plasticity in the neural circuits underlying these two forms of learning relates to the emergence of anxiety-related disorders, by compromising mechanisms of neural network synchronization. The clinical and translational implications of this model for anxiety-related disorders are discussed. Frontiers Media S.A. 2020-11-05 /pmc/articles/PMC7674975/ /pubmed/33250713 http://dx.doi.org/10.3389/fncel.2020.587053 Text en Copyright © 2020 Liu, Likhtik, Shereen, Dennis-Tiwary and Casaccia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular Neuroscience Liu, Jia Likhtik, Ekaterina Shereen, A. Duke Dennis-Tiwary, Tracy A. Casaccia, Patrizia White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination |
title | White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination |
title_full | White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination |
title_fullStr | White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination |
title_full_unstemmed | White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination |
title_short | White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination |
title_sort | white matter plasticity in anxiety: disruption of neural network synchronization during threat-safety discrimination |
topic | Cellular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674975/ https://www.ncbi.nlm.nih.gov/pubmed/33250713 http://dx.doi.org/10.3389/fncel.2020.587053 |
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