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Smoking and COVID-19: What we know so far

The ongoing COVID-19 pandemic has placed a spotlight on infectious diseases and their associations with host factors and underlying conditions. New data on the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus are entering the public domain at a rapid rate such that their distillati...

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Autores principales: Shastri, Madhur D., Shukla, Shakti D., Chong, Wai Chin, KC, Rajendra, Dua, Kamal, Patel, Rahul P., Peterson, Gregory M., O'Toole, Ronan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674982/
https://www.ncbi.nlm.nih.gov/pubmed/33246296
http://dx.doi.org/10.1016/j.rmed.2020.106237
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author Shastri, Madhur D.
Shukla, Shakti D.
Chong, Wai Chin
KC, Rajendra
Dua, Kamal
Patel, Rahul P.
Peterson, Gregory M.
O'Toole, Ronan F.
author_facet Shastri, Madhur D.
Shukla, Shakti D.
Chong, Wai Chin
KC, Rajendra
Dua, Kamal
Patel, Rahul P.
Peterson, Gregory M.
O'Toole, Ronan F.
author_sort Shastri, Madhur D.
collection PubMed
description The ongoing COVID-19 pandemic has placed a spotlight on infectious diseases and their associations with host factors and underlying conditions. New data on the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus are entering the public domain at a rapid rate such that their distillation often lags behind. To minimise weak associations becoming perceived as established paradigms, it is imperative that methodologies and outputs from different studies are appropriately critiqued and compared. In this review, we examine recent data on a potential relationship between smoking and COVID-19. While the causal role of smoking has been firmly demonstrated in regard to lung cancer and chronic obstructive pulmonary disease, such associations have the benefit of decades’ worth of multi-centre epidemiological and mechanistic data. From our analysis of the available studies to date, it appears that a relationship is emerging in regard to patients with a smoking history having a higher likelihood of developing more severe symptoms of COVID-19 disease than non-smokers. Data on whether COVID-19 has a greater incidence in smokers than non-smokers is thus far, contradictory and inconclusive. There is therefore a need for some caution to be exercised until further research has been conducted in a wider range of geographical settings with sufficient numbers of patients that have been carefully phenotyped in respect of smoking status and adequate statistical control for confounding factors.
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spelling pubmed-76749822020-11-19 Smoking and COVID-19: What we know so far Shastri, Madhur D. Shukla, Shakti D. Chong, Wai Chin KC, Rajendra Dua, Kamal Patel, Rahul P. Peterson, Gregory M. O'Toole, Ronan F. Respir Med Review Article The ongoing COVID-19 pandemic has placed a spotlight on infectious diseases and their associations with host factors and underlying conditions. New data on the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus are entering the public domain at a rapid rate such that their distillation often lags behind. To minimise weak associations becoming perceived as established paradigms, it is imperative that methodologies and outputs from different studies are appropriately critiqued and compared. In this review, we examine recent data on a potential relationship between smoking and COVID-19. While the causal role of smoking has been firmly demonstrated in regard to lung cancer and chronic obstructive pulmonary disease, such associations have the benefit of decades’ worth of multi-centre epidemiological and mechanistic data. From our analysis of the available studies to date, it appears that a relationship is emerging in regard to patients with a smoking history having a higher likelihood of developing more severe symptoms of COVID-19 disease than non-smokers. Data on whether COVID-19 has a greater incidence in smokers than non-smokers is thus far, contradictory and inconclusive. There is therefore a need for some caution to be exercised until further research has been conducted in a wider range of geographical settings with sufficient numbers of patients that have been carefully phenotyped in respect of smoking status and adequate statistical control for confounding factors. Elsevier Ltd. 2021-01 2020-11-19 /pmc/articles/PMC7674982/ /pubmed/33246296 http://dx.doi.org/10.1016/j.rmed.2020.106237 Text en © 2020 Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Shastri, Madhur D.
Shukla, Shakti D.
Chong, Wai Chin
KC, Rajendra
Dua, Kamal
Patel, Rahul P.
Peterson, Gregory M.
O'Toole, Ronan F.
Smoking and COVID-19: What we know so far
title Smoking and COVID-19: What we know so far
title_full Smoking and COVID-19: What we know so far
title_fullStr Smoking and COVID-19: What we know so far
title_full_unstemmed Smoking and COVID-19: What we know so far
title_short Smoking and COVID-19: What we know so far
title_sort smoking and covid-19: what we know so far
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674982/
https://www.ncbi.nlm.nih.gov/pubmed/33246296
http://dx.doi.org/10.1016/j.rmed.2020.106237
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