Cargando…

A Single‐Stranded DNA‐Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐DEL library, constructed in single‐stranded DNA format, allows de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bassi, Gabriele, Favalli, Nicholas, Vuk, Miriam, Catalano, Marco, Martinelli, Adriano, Trenner, Anika, Porro, Antonio, Yang, Su, Tham, Chuin Lean, Moroglu, Mustafa, Yue, Wyatt W., Conway, Stuart J., Vogt, Peter K., Sartori, Alessandro A., Scheuermann, Jörg, Neri, Dario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675038/ https://www.ncbi.nlm.nih.gov/pubmed/33240760 http://dx.doi.org/10.1002/advs.202001970

Ejemplares similares

Harnessing DNA Double-Strand Break Repair for Cancer Treatment
por: Trenner, Anika, et al.
Publicado: (2019)

Modular assembly and encoding strategies for dual-display DNA-encoded chemical libraries
por: Oehler, Sebastian, et al.
Publicado: (2021)

Stereoisomerism in Nanohoops with Heterogeneous Biaryl Linkages of E/Z- and R/S-Geometries
por: Sarkar, Parantap, et al.
Publicado: (2016)

Engineering the stereoisomeric structure of seed oil to mimic human milk fat
por: van Erp, Harrie, et al.
Publicado: (2019)

Stereoisomeric engineering of aggregation-induced emission photosensitizers towards fungal killing
por: Zhu, Wenping, et al.
Publicado: (2022)

Subphthalocyanine–tetracyanobuta-1,3-diene–aniline conjugates: stereoisomerism and photophysical properties
por: Winterfeld, Kim A., et al.
Publicado: (2019)

Novel stereoisomeric lignin-derived polycarbonates: towards the creation of bisphenol polycarbonate mimics
por: Wu, Xianyuan, et al.
Publicado: (2023)

Beyond Stereoisomeric Effects: Exploring the Importance of Intermolecular Electron Spin Interactions in Biorecognition
por: Lu, Yiyang, et al.
Publicado: (2023)

Impact of library input on the hit discovery rate in DNA-encoded chemical library selections
por: Puglioli, Sara, et al.
Publicado: (2023)

Chiral Triphenylacetic Acid Esters: Residual Stereoisomerism and Solid-State Variability of Molecular Architectures
por: Prusinowska, Natalia, et al.
Publicado: (2021)

Universal encoding of next generation DNA-encoded chemical libraries
por: Plais, Louise, et al.
Publicado: (2022)

Stereoisomeric Tris-BINOL-Menthol Bulky Monophosphites: Synthesis, Characterisation and Application in Rhodium-Catalysed Hydroformylation
por: Felgueiras, Alexandre P., et al.
Publicado: (2022)

The enhancing effect and promoting mechanisms of the stereoisomeric monoterpene alcohol esters as enhancers for drugs with different physicochemical properties
por: Wang, Heping, et al.
Publicado: (2022)

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles
por: Yuen, Tsz Ying, et al.
Publicado: (2019)

Host–guest interactions in nor-seco-cucurbit[10]uril: novel guest-dependent molecular recognition and stereoisomerism
por: Zhang, Xiaodong, et al.
Publicado: (2019)

Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines
por: Liu, Juan, et al.
Publicado: (2022)

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
por: Ferretti, Lorenza P., et al.
Publicado: (2016)

Modular DNA strand-displacement controllers for directing material expansion
por: Fern, Joshua, et al.
Publicado: (2018)

Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1
por: Catalano, Marco, et al.
Publicado: (2020)

Behavioral Responses of the Invasive Halyomorpha halys (Stål) to Traps Baited with Stereoisomeric Mixtures of 10,11-Epoxy-1-bisabolen-3-OL
por: Leskey, Tracy C., et al.
Publicado: (2015)

New synthesis of a stereoisomeric mixture of methyl 12-trishomofarnesoate, a juvenile hormone mimic useful in sericulture by increasing silk production
por: MORI, Kenji
Publicado: (2017)

Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo
por: Salomatina, Oksana V., et al.
Publicado: (2022)

Substrate stereoselectivity of poly(Asp) hydrolase-1 capable of cleaving β-amide bonds as revealed by investigation of enzymatic hydrolysis of stereoisomeric β-tri(Asp)s
por: Hiraishi, Tomohiro, et al.
Publicado: (2015)

The Double-Stranded DNA Virosphere as a Modular Hierarchical Network of Gene Sharing
por: Iranzo, Jaime, et al.
Publicado: (2016)

Exposing the distinctive modular behavior of β-strands and α-helices in folded proteins
por: Wang, Huabing, et al.
Publicado: (2020)

Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing
por: Talluri, Ravi S., et al.
Publicado: (2009)

One out of Four: Kinetic Resolution of Stereoisomeric Mixtures of Secondary Alcohols with a Quaternary Carbon Atom in the β-Position by Cu–H-Catalyzed Enantioselective Silylation
por: Papadopulu, Zaneta, et al.
Publicado: (2021)

The stereoisomeric Bacillus subtilis HN09 metabolite 3,4-dihydroxy-3-methyl-2-pentanone induces disease resistance in Arabidopsis via different signalling pathways
por: Liu, Niu, et al.
Publicado: (2019)

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2022)

Double-Strand Breaks from a Radical Commonly Produced by DNA-Damaging Agents
por: Taverna Porro, Marisa L., et al.
Publicado: (2015)

Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides: Synthesis of Novel Stereoisomeric Octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones
por: Said, Awad I., et al.
Publicado: (2020)

Giant intraoral condyloma accuminatum lesion coexisting with genital condyloma
por: Ozdamar, S.Serap Moroglu, et al.
Publicado: (2014)

A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection
por: Kuster, Anika, et al.
Publicado: (2021)

Lectures on Hilbert modular varieties and modular forms
por: Goren, Eyal Z
Publicado: (2001)

Modular and Hierarchically Modular Organization of Brain Networks
por: Meunier, David, et al.
Publicado: (2010)

A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids
por: Trenner, Johanna, et al.
Publicado: (2015)

Modularity and anti-modularity in networks with arbitrary degree distribution
por: Hintze, Arend, et al.
Publicado: (2010)

Deep Learning Approach for the Discovery of Tumor-Targeting Small Organic Ligands from DNA-Encoded Chemical Libraries
por: Torng, Wen, et al.
Publicado: (2023)

Modular units
por: Kubert, Daniel S, et al.
Publicado: (1981)

Modularity defined
por: Sauro, Herbert M
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_t9c1e8c8r1h5bit13pjhj65mpf